Browsing by Keywords "Selenium"

Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism?

Irmak, M. B.; Ince, G.; Ozturk, M.; Cetin Atalay, R. (American Association for Cancer Research, 2003)

Selenium is essential to human health, and its deficiency is associated with different diseases including liver necrosis. Selenium is protective against viral hepatitis and hepatocellular carcinoma (HCC). The underlying ...

Characterization of programmed cell death induced by oxidative stress in selenium - deficient hepatocellular carcinoma cells

İnce, Gülayşe (Bilkent University, 1999)

Selenium (Se) plays an important role in eliminating the reactive oxygen species generated during oxidative stress. Se-containing selenocysteine is an essential amino acid required for the synthesis of many selenoproteins, ...

Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium

Erkekoglu, P.; Rachidi, W.; Yuzugullu, O. G.; Giray, B.; Favier, A.; Ozturk, M.; Hincal, F. (Elsevier, 2010)

Di(2-ethylhexyl)-phthalate (DEHP) is the most abundantly used phthalate derivative, inevitable environmental exposure of which is suspected to contribute to the increasing incidence of testicular dysgenesis syndrome in ...

Induction of ROS, p53, p21 in DEHP-and MEHP-exposed LNCaP cells-protection by selenium compunds

Erkekoglu, P.; Rachidi, W.; Yazgullu, O. G.; Giray, B.; Ozturk, M.; Favier, A.; Hincal, F. (Elsevier, 2011-07)

This study was designed to investigate the hypothesis that the toxic effects of di(2-ethylhexyl)phthalate (DEHP), the most abundantly used plasticizer and ubiquitous environmental contaminant that cause alterations in ...

Macroscopic photoconductive nanowire arrays

Bayındır, Mehmet; Yaman, Mecit; Özgür, Erol; Aktaş, Ozan; Khudiyev, Tural; Kanık, Mehmet; Deniz, Hakan (IEEE, 2011)

A novel high-throughput fabrication technique to produce polymer embedded functional chalcogenide nanowire arrays is demonstrated. Indefinitely-long selenium nanowire arrays are obtained and their size dependent photoconductivity ...

Na+/I-symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormones

Akturk, M.; Oruc, A.S.; Danisman, N.; Erkek, S.; Buyukkagnici, U.; Unlu, E.; Tazebay, U.H. (2013)

Placental type 3 iodothyronine deiodinase (D3) potentially protects the fetus from the elevated maternal thyroid hormones. Na+/I- symporter (NIS) is a plasma membrane glycoprotein, which mediates active iodide uptake. Our ...

SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer

Sayan, A. E.; Griffiths, T. R.; Pal, R.; Browne G. J.; Ruddick, A.; Yagci, T.; Edwards, R.; Mayer, N. J.; Qazi, H.; Goyal, S.; Fernandez, S.; Straatman, K.; Jones G. D. D.; Bowman, K. J.; Colquhoun, A.; Mellon, J. K.; Kriajevska, M.; Tulchinsky, E. (National Academy of Sciences, 2009)

The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB family members, ZEB1 and ZEB2(SIP1), inhibit transcription of the E-cadherin gene and induce EMT in vitro. However, their relevance to ...

Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells

Gözen, D.; Kahraman, D. C.; Narcı, K.; Shehwana, H.; Konu, Özlen; Çetin-Atalay, Rengül (Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2021-04-20)

Hepatocellular carcinoma (HCC) is one of the most common cancer types with high mortality rates and displays increased resistance to various stress conditions such as oxidative stress. Conventional therapies have low ...