Now showing items 1-4 of 4

    • Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication 

      Montague, M. J.; Li, G.; Gandolfi, B.; Khan, R.; Aken, B. L.; Marques Bonet, T.; Alkan C.; Thomas, G. W. C.; Warren, W. C.; Searle, S. M. J.; Minx, M.; Hilliera, LaDeana W.; Koboldt, D. C.; Davis, B. W.; Driscoll, C. A.; Barr, C. S.; Blackistone, K.; Quilez, J.; Lorente-Galdos, B.; Marques Bonet, T.; Hahnj, M. W.; Menotti-Raymond, M.; O’Brien, S. J.; Wilson, R. K.; Lyons, L. A.; Murphy, W. J. (Proceedings of the National Academy of SciencesNational Academy of Sciences, 2014-12-02)
      Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with ...
    • Demographically-based evaluation of genomic regions under selection in domestic dogs 

      Freedman, A. H.; Schweizer, R. M.; Vecchyo, D. Ortega-Del; Han, E.; Davis, B. W.; Gronau, I.; Silva, P. M.; Galaverni, M.; Fan, Z.; Marx, P.; Lorente-Galdos, B.; Ramirez, O.; Hormozdiari, F.; Alkan C.; Vilà, C.; Squire K.; Geffen, E.; Kusak, J.; Boyko, A. R.; Parker, H. G.; Lee C.; Tadigotla, V.; Siepel, A.; Bustamante, C. D.; Harkins, T. T.; Nelson, S. F.; Marques Bonet, T.; Ostrander, E. A.; Wayne, R. K.; Novembre, J. (Public Library of Science, 2016)
      Controlling for background demographic effects is important for accurately identifying loci that have recently undergone positive selection. To date, the effects of demography have not yet been explicitly considered when ...
    • Extremely skewed X-chromosome inactivation is increased in pre-eclampsia 

      Uz, E.; Dolen, I.; Al, A. R.; Ozcelik, T. (Springer-Verlag, 2007-03)
      Pre-eclampsia is a disorder that affects approximately 5% of pregnancies. We tested the hypothesis that skewed X-chromosome inactivation (XCI) could be involved in the pathogenesis of pre-eclampsia. Peripheral blood DNA ...
    • Great ape genetic diversity and population history 

      Prado-Martinez, J.; Eichler, E. E.; Marques-Bonet, T.; Sudmant, P. H.; Kidd, J. M.; Li, H.; Kelley, J. L.; Lorente-Galdos, B.; Veeramah, K. R.; Woerner, A. E.; O’Connor, T. D.; Santpere, G.; Cagan, A.; Theunert, C.; Casals, F.; Laayouni, H.; Munch, K.; Hobolth, A.; Halager, A. E.; Malig, M.; Hernandez-Rodriguez, J.; Hernando-Herraez, I.; Prüfer, K.; Pybus, M.; Johnstone, L.; Lachmann, M.; Alkan C.; Twig, D.; Petit, N.; Baker, C.; Hormozdiari, F.; Fernandez-Callejo, M.; Dabad, M.; Wilson, M. L.; Stevison, L.; Camprubí, C.; Carvalho, T.; RuizHerrera, A.; Vives, L.; Mele, M.; Abello, T.; Kondova, I.; Bontrop, R. E.; Pusey, A.; Lankester, F.; Kiyang, J. A.; Bergl, R. A.; Lonsdorf, E.; Myers, S.; Ventura, M.; Gagneux, P.; Comas, D.; Siegismund, H.; Blanc, J.; Agueda-Calpena, L.; Gut, M.; Fulton, L.; Tishkoff, S. A.; Mullikin, J. C.; Wilson, R. K.; Gut, I. G.; Gonder, M K.; Ryder, O. A.; Hahn, B. H.; Navarro, A.; Akey, J. M.; Bertranpetit, J.; Reich, D.; Mailund, T.; Schierup, M. H.; Hvilsom, C.; Andrés, A. M.; Wall, J. D.; Bustamante, C. D.; Hammer, M. F. (Nature Publishing Group, 2013)
      Most great ape genetic variation remains uncharacterized(1,2); however, its study is critical for understanding population history(3-6), recombination(7), selection(8) and susceptibility to disease(9,10). Here we sequence ...