Now showing items 1-2 of 2

    • Paralog-specific gene copy number discovery within segmental duplications 

      Doğru, Emre (Bilkent University, 2019-09)
      With the advancing technology in genome sequencing and analysis, it has become evident that the structural variations are the main source of alteration in human genome. Despite their signi cance in understanding disease ...
    • Reconstructing complex regions of genomes using long-read sequencing technology 

      Huddleston, J.; Ranade, S.; Malig, M.; Antonacci, F.; Chaisson, M.; Hon, L.; Sudmant, P. H.; Alkan C.; Eichler, E. E.; Graves, T. A.; Dennis, M. Y.; Wilson, R. K.; Turner, S. W.; Korlach, J. (Cold Spring Harbor Laboratory Press, 2014)
      Obtaining high-quality sequence continuity of complex regions of recent segmental duplication remains one of the major challenges of finishing genome assemblies. In the human and mouse genomes, this was achieved by targeting ...