Now showing items 1-2 of 2

    • The SOCS-1 gene methylation in chronic myeloid leukemia patients 

      Hatirnaz, O.; Ure, U.; Ar, C.; Akyerli, C.; Soysal, T.; Ferhanoǧlu, B.; Özçelik, T.; Ozbek, U. (John Wiley & Sons, Inc., 2007)
      SOCS-1, an important protein in the JAK/STAT pathway, has a role in the down stream of BCR-ABL protein kinase. We investigated 56 CML patients and 16 controls for the methylation status of SOCS-1 gene promoter and Exon 2 ...
    • Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides 

      Bayik D.; Gursel, I.; Klinman, D. M. (Academic Press, 2016)
      Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and ...