Browsing by Keywords "Reduced nicotinamide adenine dinucleotide phosphate oxidase 4"

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Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth

Şentürk, Şerif; Mumcuoğlu, Mine; Gürsoy-Yüzügüllü, Özge; Cingöz, Burcu; Akçalı, Kamil Can; Öztürk, Mehmet (American Association for the Study of Liver Disease, 2010)

Senescence induction could be used as an effective treatment for hepatocellular carcinoma (HCC). However, major senescence inducers (p53 and p16Ink4a) are frequently inactivated in these cancers.We tested whether transforming ...