Now showing items 1-2 of 2

    • Functionally conserved effects of rapamycin exposure on zebrafish 

      Sucularli, C.; Shehwana, H.; Kuscu, C.; Dungul, D. C.; Ozdag, H.; Konu, O. (Spandidos Publications, 2016-03)
      Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase important in cell proliferation, growth and protein translation. Rapamycin, a well-known anti-cancer agent and immunosuppressant drug, inhibits ...
    • IKBKE inhibits TSC1 to activate the mTOR/S6K pathway for oncogenic transformation 

      Göktuna, S. İ. (Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2018)
      IKBKE (IKKε) has emerged as a key modulator of multiple substrates, controlling oncogenic pathways in various malignancies. mTOR signaling, required for cellular growth, proliferation, and vascular angiogenesis in cancer, ...