Now showing items 1-16 of 16

    • Atomic force microscopy for the investigation of molecular and cellular behavior 

      Ozkan A.D.; Topal, A. E.; Dana, A.; Guler, M. O.; Tekinay, A. B. (Elsevier, 2016-10)
      The present review details the methods used for the measurement of cells and their exudates using atomic force microscopy (AFM) and outlines the general conclusions drawn by the mechanical characterization of biological ...
    • Chromatin-modifying enzymes as modulators of reprogramming 

      Onder, T. T.; Kara, N.; Cherry, A.; Sinha, A. U.; Zhu, N.; Bernt, K. M.; Cahan, P.; Marcarci, B. O.; Unternaehrer, J.; Gupta, P. B.; Lander, E. S.; Armstrong, S. A.; Daley, G. Q. (Nature Publishing Group, 2012)
      Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated with the distinct epigenetic ...
    • Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication 

      Montague, M. J.; Li, G.; Gandolfi, B.; Khan, R.; Aken, B. L.; Marques Bonet, T.; Alkan C.; Thomas, G. W. C.; Warren, W. C.; Searle, S. M. J.; Minx, M.; Hilliera, LaDeana W.; Koboldt, D. C.; Davis, B. W.; Driscoll, C. A.; Barr, C. S.; Blackistone, K.; Quilez, J.; Lorente-Galdos, B.; Marques Bonet, T.; Hahnj, M. W.; Menotti-Raymond, M.; O’Brien, S. J.; Wilson, R. K.; Lyons, L. A.; Murphy, W. J. (Proceedings of the National Academy of SciencesNational Academy of Sciences, 2014-12-02)
      Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with ...
    • Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma 

      Bozdogan, O.; Yulug, I. G.; Vargel, I.; Cavusoglu, T.; Karabulut, A. A.; Karahan, G.; Sayar, N. (Wiley-Blackwell Publishing Ltd., 2015)
      Background: Basal cell carcinomas (BCCs) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of the ...
    • Finite size effects in cooperative molecular motors 

      Taneri, S.; Yalabik, M. C. (Elsevier B.V., 2003)
      We have studied the ballistic and damped dynamics of finite size cooperative molecular motors. We study the effect of finite size on average quantities such as sliding velocity, as well as the statistics of fluctuations ...
    • Functionally conserved effects of rapamycin exposure on zebrafish 

      Sucularli, C.; Shehwana, H.; Kuscu, C.; Dungul, D. C.; Ozdag, H.; Konu, O. (Spandidos Publications, 2016-03)
      Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase important in cell proliferation, growth and protein translation. Rapamycin, a well-known anti-cancer agent and immunosuppressant drug, inhibits ...
    • Genetic analysis of MEFV gene pyrin domain in patients with Behçet's disease 

      Dursun, A.; Durakbasi-Dursun, H. G.; Zamani, A. G.; Gulbahar, Z. G.; Dursun, R.; Yakicier, C. (Hindawi Publishing Corporation, 2006)
      Objectives. Behçet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility ...
    • Homozygosity mapping and targeted genomic sequencing reveal the game responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred 

      Gulsuner, S.; Tekinay, A. B.; Doerschner, K.; Boyaci, H.; Bilguvar, K.; Unal, H.; Ors, A.; Onat, O. E.; Atalar, E.; Basak, A. N.; Topaloglu, H.; Kansu, T.; Tan, M.; Tan, U.; Gunel, M.; Ozcelik, T. (Cold Spring Harbor Laboratory Press, 2011-09-01)
      The biological basis for the development of the cerebro-cerebellar structures required for posture and gait in humans is poorly understood. We investigated a large consanguineous family from Turkey exhibiting an extremely ...
    • Identification of relative protein bands in polyacrylamide gel electrophoresis (PAGE) using a multi-resolution snake algorithm 

      Gürcan, M. N.; Koyutürk, M.; Yildiz, H. S.; Çetin-Atalay R.; Çetin, A. E. (Informa Healthcare, 1999-06)
      In polyacrylamide gel electrophoresis (PAGE) image analysis, it is important to determine the percentage of the protein of interest of a protein mixture. This study presents reliable computer software to determine this ...
    • Immunization with UV-induced apoptotic cells generates monoclonal antibodies against proteins differentially expressed in hepatocellular carcinoma cell lines 

      Celikkaya, H.; Ciraci, C.; Oztas, E.; Avci, M. E.; Ozturk, M.; Yagci, T. (Mary Ann Liebert, Inc, 2007)
      Early and differential diagnosis of hepatocellular carcinoma (HCC) requires sensitive and specific tissue and serum markers. On the other hand, proteins involved in tumorigenesis are extensively modelated on exposure to ...
    • Mutations in RAD21 disrupt regulation of apob in patients with chronic intestinal pseudo-obstruction 

      Bonora, E.; Bianco, F.; Cordeddu, L.; Bamshad, M.; Francescatto, L.; Dowless, D.; Stanghellini, V.; Cogliandro, R. F.; Lindberg, G.; Mungan, Z.; Cefle, K.; Ozcelik, T.; Palanduz, S.; Ozturk, S.; Gedikbasi, A.; Gori, A.; Pippucci, T.; Graziano, C.; Volta, U.; Caio, G.; Barbara, G.; D'Amato, M.; Seri, M.; Katsanis, N.; Romeo, G.; De Giorgio, R. (W.B. Saunders, 2015)
      Background Aims Chronic intestinal pseudo-obstruction (CIPO) is characterized by severe intestinal dysmotility that mimics a mechanical subocclusion with no evidence of gut obstruction. We searched for genetic variants ...
    • Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges 

      Toren, P.; Ozgur E.; Bayindir, M. (Royal Society of Chemistry, 2016)
      This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems. ...
    • Protein folding rates correlate with heterogeneity of folding mechanism 

      Öztop, B.; Ejtehadi, M. R.; Plotkin, S. S. (American Physical Society, 2004)
      The folding rates of protein were shown to correlate with the degree of heterogeneity in the formation of native contacts. It was shown that both experimental rates and simulated free energy barriers for 2-state proteins ...
    • Regulation of Homer and group I metabotropic glutamate receptors by nicotine 

      Kane, J. K.; Hwang, Y.; Konu, O.; Loughlin, S. E.; Leslie, F. M.; Li, M. D. (Wiley-Blackwell Publishing Ltd., 2005)
      The present study focuses on the nicotine-induced modulation of mRNA and protein expression of a number of genes involved in glutamatergic synaptic transmission in rat brain over different time periods of exposure. A ...
    • TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT 

      Hill, R.; Madureira, P. A.; Ferreira, B.; Baptista, I.; Machado, S.; Colaço, L.; Dos Santos, M.; Liu, N.; Dopazo, A.; Ugurel, S.; Adrienn, A.; Kiss-Toth, E.; Isbilen, M.; Gure, A. O.; Link, W. (Nature Publishing Group, 2017)
      Intrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment failure for many cancer patients. The identification of molecular mechanisms involved in drug resistance or sensitization is imperative. ...
    • Two learning approaches for protein name extraction 

      Tatar, S.; Cicekli, I. (Academic Press, 2009)
      Protein name extraction, one of the basic tasks in automatic extraction of information from biological texts, remains challenging. In this paper, we explore the use of two different machine learning techniques and present ...