Browsing by Keywords "Prognosis"
Now showing items 1-20 of 21
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A-To-I RNA editing events, potential biomarkers for prognosis and chemosensitivity in gastric cancer
(Bilkent University, 2022-09)Gastric cancer (GC) is one of the leading causes of cancer mortality, and it frequently presents in advanced stages with a poor prognosis and response to treatment. Although extensive research has identified many potential ... -
CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer
(Springer, 2021-04)Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of ... -
A combined ULBP2 and SEMA5A expression signature as a prognostic and predictive biomarker for colon cancer
(Ivyspring International Publisher, 2017)Background: Prognostic biomarkers for cancer have the power to change the course of disease if they add value beyond known prognostic factors, if they can help shape treatment protocols, and if they are reliable. The aim ... -
Discovery of cancer-specific and independent prognostic gene subsets of the slit-robo family using TCGA-PANCAN datasets
(Mary Ann Liebert, 2021-12-08)The Slit-Robo family of axon guidance molecules works in concert, playing important roles in organ devel opment and cancer. Expressions of individual Slit-Robo genes have been used in calculating univariable hazard ratios ... -
Endothelial progenitor cells display clonal restriction in multiple myeloma
(BioMed Central Ltd., 2006)Background: In multiple myeloma (MM), increased neoangiogenesis contributes to tumor growth and disease progression. Increased levels of endothelial progenitor cells (EPCs) contribute to neoangiogenesis in MM, and, ... -
Expression of CK-19 and CEA mRNA in peripheral blood of gastric cancer patients
(2010)Aim: To investigate the clinical and pathological relevance of detection of circulating tumor cells (CTC) in the peripheral blood of gastric carcinoma patients before operation. Patients and Methods: Fifty patients with ... -
Expression of IFITM1 in chronic myeloid leukemia patients
(Elsevier, 2005)We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 ... -
Identification and utilization of autologous anti-tumor antibodies for the diagnosis and prognosis of cancer
(Bilkent University, 2015-12)Lung cancer is the leading cause of cancer related death worldwide. Current diagnostic methods have limited power and unable to extend patient life significantly. SCLC; the most aggressive subtype of lung cancer is an ... -
Identification of theranostic gene markers in cancers and prognostic validation in colorect al cancer
(Bilkent University, 2015-01)Colorectal cancer (CRC) is the fourth most prevalent cancer type worldwide. Although the 5-year survival rate of CRC is higher than many cancer types, prediction of prognosis and identification of accurate biomarkers still ... -
In silico validation of prognostic mRNA signature in gastric cancer and identification and validation of novel gastric tissue specific reference genes for quantitative PCR
(Bilkent University, 2021-07)Gastric adenocarcinoma is a molecularly and histologically heterogeneous neoplasm with a predictively disastrous outcome if undiagnosed at early stages. Amidst global declines of gastric cancer rates, it remains the 5th ... -
Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer
(Springer Netherlands, 2017-09)Purpose: Aldo-keto reductases (including AKR1B1 and AKR1B10) constitute a family of oxidoreductases that have been implicated in the pathophysiology of diabetes and cancer, including colorectal cancer (CRC). Available data ... -
Precariousness, the secured present and the sustainability of the future: learning from Koselleck and extrapolating from Elias
(Sage Publications Ltd., 2008)Theorists concerned with the current status of the future have rightly acknowledged their debt to Koselleck’s historicization of modern future-oriented temporality. Koselleck, however, does not address how such a temporality ... -
Prediction of prognosis and chemosensitivity in gastrointestinal cancers
(Bilkent University, 2017-12)Colon and gastric cancers are the third and fifth cancer types with the poorest survival. Surgery is considered the primary treatment option, which can be curative. However the decision as to whether chemotherapy ... -
Renin angiotensin system genes are biomarkers for personalized treatment of acute myeloid leukemia with Doxorubicin as well as etoposide
(Public Library of Science, 2020)Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling studies have thus far revealed the presence ... -
A shiny application for pancan survival analysis with paralog/miRNA pairs and in vitro validation of miRNA synergism in liver cancer
(Bilkent University, 2022-09)Emerging cancer survival tools can predict risk of disease and identify prognostic biomarkers. Multivariable Cox proportional hazards models with mRNA and microRNAs (miRNAs) expression can differentiate survival outcomes. ... -
Simultaneous miRNA and mRNA transcriptome profiling of glioblastoma samples reveals a novel set of OncomiR candidates and their target genes
(Elsevier, 2018)Although glioblastomas are common, there remains a need to elucidate the underlying mechanisms behind their initiation and progression and identify molecular pathways for improving treatment. In this study, sixteen ... -
SmulTCan: A Shiny application for multivariable survival analysis of TCGA data with gene sets
(Elsevier Ltd, 2021-10)Background Survival analysis is widely used in cancer research, and although several methods exist in R, there is the need for a more interactive, flexible, yet comprehensive online tool to analyze gene sets using Cox ... -
SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome
(Lippincott Williams & Wilkins, 2008)BACKGROUND/OBJECTIVE: We reported that 43% of patients with Lambert-Eaton myasthenic syndrome (LEMS) and small cell lung cancer (SCLC) had an antibody called anti-glial nuclear antibody (AGNA), defined by the immunoreaction ... -
Survival analysis and its applications in identifying genes, signatures, and pathways in human cancers
(Bilkent University, 2021-09)Cancer literature makes use of survival analyses focused on gene expression based on univariable or multivariable regression. However, there is still a need to understand whether a) incorporating exon or isoform information ... -
Transcript variants of CELF2 gene as unique prognostic indicators in breast cancer
(Bilkent University, 2022-08)Breast cancer (BC) is the most common malignant tumor in women around the world. Aside from finding a cure for this disease, it is also critical to identify prognostic biomarkers that can help clinicians intervene with the ...
