Browsing by Keywords "Pharmacophore analysis"

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Evaluation of inhibitory effects of benzothiazole and 3-amino-benzothiazolium derivatives on DNA topoisomerase II by molecular modeling studies

Akı-Yalçın, E.; Ertan-Bolelli, T.; Taşkın-Tok, T.; Öztürk, Ö.; Ataei, S.; Özen, Çiğdem; Yıldız, I.; Yalçın, I. (Taylor and Francis, 2014)

There has been considerable interest in DNA topoisomerases over the last decade, as they have been shown to be one of the major cellular targets in anticancer drug development. Previously we synthesized some benzothiazole ...