Browsing by Keywords "Pathology"

Adjuvant autologous melanoma vaccine for macroscopic stage III disease: survival, biomarkers, and improved response to CTLA-4 blockade

Lotem, M.; Merims, S.; Frank, S.; Hamburger, T.; Nissan, A.; Kadouri, L.; Cohen, J.; Straussman, R.; Eisenberg, G.; Frankenburg, S.; Carmon, E.; Alaiyan, B.; Shneibaum, S.; Ayyildiz, Z. O.; Isbilen, M.; Senses, K. M.; Ron, I.; Steinberg, H.; Smith, Y.; Shiloni, E.; Gure, A. O.; Peretz, T. (Hindawi Limited, 2016)

Background. There is not yet an agreed adjuvant treatment for melanoma patients with American Joint Committee on Cancer stages III B and C. We report administration of an autologous melanoma vaccine to prevent disease ...

Angiogenic peptide nanofibers repair cardiac tissue defect after myocardial infarction

Rufaihah, A. J.; Yasa, I. C.; Ramanujam, V. S.; Arularasu, S. C.; Kofidis, T.; Guler, M. O.; Tekinay, A. B. (Acta Materialia Inc, 2017)

Myocardial infarction remains one of the top leading causes of death in the world and the damage sustained in the heart eventually develops into heart failure. Limited conventional treatment options due to the inability ...

Automated cancer stem cell recognition in H and E stained tissue using convolutional neural networks and color deconvolution

Aichinger, W.; Krappe, S.; Cetin, A. E.; Cetin Atalay, R.; Üner A.; Benz, M.; Wittenberg, T.; Stamminger, M.; Münzenmayer, C. (SPIE, 2017)

The analysis and interpretation of histopathological samples and images is an important discipline in the diagnosis of various diseases, especially cancer. An important factor in prognosis and treatment with the aim of a ...

Distribution of aortic mechanical prosthetic valve closure sound model parameters on the surface of the chest

Baykal, A.; İder, Y. Z.; Köymen, H. (Institute of Electrical and Electronics Engineers, 1995-04)

It has been previously proposed that heart valve closure sounds can be modeled by a sum of decaying sinusoids, based on the hypothesis that the heart cavity, heart walls, major vessels, and other structures in the chest ...

Gemcitabine integrated nano-prodrug carrier system

Hamsici, S.; Ekiz, M. S.; Ciftci, G. C.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2017)

Peptide nanomaterials have received a great deal of interest in drug-delivery applications due to their biodegradability, biocompatibility, suitability for large-scale synthesis, high drug-loading capacities, targeting ...

Inhibition of VEGF mediated corneal neovascularization by anti-angiogenic peptide nanofibers

Senturk, B.; Cubuk, M. O.; Ozmen, M. C.; Aydin B.; Guler, M. O.; Tekinay, A. B. (Elsevier, 2016-11)

Atypical angiogenesis is one of the major symptoms of severe eye diseases, including corneal neovascularization, and the complex nature of abnormal vascularization requires targeted methods with high biocompatibility. The ...

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

Gao J.; Aksoy, B. A.; Dogrusoz, U.; Dresdner, G.; Gross, B.; Sumer, S. O.; Sun, Y.; Jacobsen, A.; Sinha, R.; Larsson, E.; Cerami, E.; Sander, C.; Schultz, N. (American Association for the Advancement of Science (A A A S), 2013)

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer ...

Jnk1 deficiency in hematopoietic cells suppresses macrophage apoptosis and increases atherosclerosis in low-density lipoprotein receptor null mice

Babaev, V. R.; Yeung, M.; Erbay, E.; Ding, L.; Zhang, Y.; May, J. M.; Fazio, S.; Hotamisligil, G. S.; Linton, M. F. (Lippincott Williams and Wilkins, 2016)

Objective - The c-Jun NH 2 -terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling. Macrophages express 2 JNK isoforms, JNK1 and JNK2, which may have ...

Mammalian telomeric DNA suppresses endotoxin-induced uveitis

Yagci, F. C.; Aslan, O.; Gursel, M.; Tincer, G.; Özdamar, Y.; Karatepe, K.; Akcali, K. C.; Gursel, I. (American Society for Biochemistry and Molecular Biology Inc., 2010)

Telomeric regions of mammalian chromosomes contain suppressive TTAGGG motifs that inhibit several proinflammatory and Th1-biased immune responses. Synthetic oligodeoxynucleotides (ODN) expressing suppressive motifs can ...

Metastasis suppressor proteins in cutaneous squamous cell carcinoma

Bozdogan, O.; Vargel, I.; Cavusoglu, T.; Karabulut, A. A.; Karahan, G.; Sayar, N.; Atasoy, P.; Yulug, I. G. (Elsevier, 2016-07)

Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. ...

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

Mutlu, M.; Raza, U.; Saatci, Ö.; Eyüpoğlu, E.; Yurdusev, E.; Şahin, Ö. (Springer Verlag, 2016-06)

MicroRNAs (miRNAs) are 20–22-nucleotide small endogenous non-coding RNAs which regulate gene expression at post-transcriptional level. In the last two decades, identification of almost 2600 miRNAs in human and their potential ...

The prosurvival IKK-related kinase IKKϵ integrates LPS and IL17A signaling cascades to promote Wnt-dependent tumor development in the intestine

Göktuna, S. I.; Shostak, K.; Chau, T.-L.; Heukamp, L.C.; Hennuy, B.; Duong, H.-Q.; Ladang, A.; Close, P.; Klevernic, I.; Olivier, F.; Florin, A.; Ehx, G.; Baron, F.; Vandereyken, M.; Rahmouni, S.; Vereecke, L.; Loo, G. V.; Büttner, R.; Greten, F. R.; Chariot, A. (American Association for Cancer Research, 2016-05)

Constitutive Wnt signaling promotes intestinal cell proliferation, but signals from the tumor microenvironment are also required to support cancer development. The role that signaling proteins play to establish a tumor ...

Quantification of SLIT-ROBO transcripts in hepatocellular carcinoma reveals two groups of genes with coordinate expression

Avci, M. E.; Konu, O.; Yagci, T. (BioMed Central, 2008)

Background: SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, ...

Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair

Karahaliloǧlu, Z.; Demirbilek, M.; Şam, M.; Saǧlam, N.; Mizrak, A. K.; Denkbaş, E. B. (Taylor and Francis Ltd., 2016)

The aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun ...

Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines

Mustufa, M. A.; Hashmi, I. A.; Manzoor, S.; Ahmed, A.; Ahmed, Viqar-ud-din; Aslam, A.; Ozen, C.; Naqvi, Naim ul Hasan; Ozturk, M.; Ali, F. I. (Pakistan Journal of Pharmaceutical Sciences, 2014)

Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca ...

Two-tier tissue decomposition for histopathological image representation and classification

Gultekin, T.; Koyuncu, C. F.; Sokmensuer, C.; Gunduz Demir, C. (Institute of Electrical and Electronics Engineers, 2015)

In digital pathology, devising effective image representations is crucial to design robust automated diagnosis systems. To this end, many studies have proposed to develop object-based representations, instead of directly ...

Unsupervised feature extraction via deep learning for histopathological classification of colon tissue images

Sari, C. T.; Gunduz Demir, C. (Institute of Electrical and Electronics Engineers, 2018)

Histopathological examination is today’s gold standard for cancer diagnosis. However, this task is time consuming and prone to errors as it requires a detailed visual inspection and interpretation of a pathologist. ...