Browsing by Keywords "P21(ink4a)"

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p53 but not p16(INK4a) induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells

Morel, A. P.; Unsal, K.; Cagatay, T.; Ponchel, F.; Carr, B.; Ozturk, M. (Elsevier, 2000-08)

Background/Aim: Both p16(INK4a) and p53 proteins are negative regulators of the cell cycle. In human hepatocellular carcinomas (HCC), the loss of function of p53, retinoblastoma (pRb) and p16(INK4a) genes by different ...