Browsing by Keywords "Nanofiber"

Alkaline phosphatase-mimicking peptide nanofibers for osteogenic differentiation

Gulseren, G.; Yasa, I. C.; Ustahuseyin, O.; Tekin, E. D.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2015)

Recognition of molecules and regulation of extracellular matrix synthesis are some of the functions of enzymes in addition to their catalytic activity. While a diverse array of enzyme-like materials have been developed, ...

Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds

Uzunalli, G.; Mammadov R.; Yesildal, F.; Alhan, D.; Ozturk, S.; Ozgurtas, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2017)

Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of ...

Angiogenic peptide nanofibers improve wound healing in STZ-induced diabetic rats

Senturk, B.; Mercan, S.; Delibasi, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2016-06)

Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity ...

Angiogenic peptide nanofibers repair cardiac tissue defect after myocardial infarction

Rufaihah, A. J.; Yasa, I. C.; Ramanujam, V. S.; Arularasu, S. C.; Kofidis, T.; Guler, M. O.; Tekinay, A. B. (Acta Materialia Inc, 2017)

Myocardial infarction remains one of the top leading causes of death in the world and the damage sustained in the heart eventually develops into heart failure. Limited conventional treatment options due to the inability ...

Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes

Celebioglu A.; Umu, O. C. O.; Tekinay, T.; Uyar T. (Elsevier, 2014)

The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were ...

Antibacterial electrospun zein nanofibrous web encapsulating thymol/cyclodextrin-inclusion complex for food packaging

Aytac Z.; Ipek, S.; Durgun, E.; Tekinay, T.; Uyar T. (Elsevier, 2017-10)

Thymol (THY)/γ-Cyclodextrin(γ-CD) inclusion complex (IC) encapsulated electrospun zein nanofibrous webs (zein-THY/γ-CD-IC-NF) were fabricated as a food packaging material. The formation of THY/γ-CD-IC (1:1 and 2:1) was ...

Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers

Aytac Z.; Uyar T. (Elsevier, 2016-06)

Cyclodextrin inclusion complexes (CD-ICs) can be encapsulated into electrospun nanofibers in order to achieve delivery systems having high surface area and highly porous nanofibrous structures. In this study, a well-known ...

Antioxidant vitamin E/cyclodextrin inclusion complex electrospun nanofibers: enhanced water solubility, prolonged shelf life, and photostability of vitamin E

Celebioglu A.; Uyar T. (American Chemical Society, 2017)

Here, we demonstrated the electrospinning of polymer-free nanofibrous webs from inclusion complex (IC) between hydroxypropyl-β-cyclodextrin (HPβCD) and Vitamin E (Vitamin E/HPβCD-IC NF). The inclusion complexation between ...

Bacteria encapsulated electrospun nanofibrous webs for remediation of methylene blue dye in water

Sarioglu O.F.; Keskin, N. O. S.; Celebioglu A.; Tekinay, T.; Uyar T. (Elsevier, 2017-04)

In this study, preparation and application of novel biocomposite materials that were produced by encapsulation of bacterial cells within electrospun nanofibrous webs are described. A commercial strain of Pseudomonas ...

Bacteria immobilized electrospun polycaprolactone and polylactic acid fibrous webs for remediation of textile dyes in water

Sarioglu O.F.; S. Keskin, N. O.; Celebioglu A.; Tekinay, T.; Uyar T. (Elsevier, 2017-10)

In this study, preparation and application of novel biocomposite materials for textile dye removal which are produced by immobilization of specific bacteria onto electrospun nanofibrous webs are presented. A textile dye ...

Bioactive self-assembled peptide nanofibers for corneal stroma regeneration

Uzunalli, G.; Soran, Z.; Erkal, T. S.; Dagdas, Y. S.; Dinc, E.; Hondur, A. M.; Bilgihan, K.; Aydin B.; Guler, M. O.; Tekinay, A. B. (Elsevier, 2014)

Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential ...

Bioactive supramolecular peptide nanofibers for regenerative medicine

Arslan, E.; Garip, I. C.; Gulseren, G.; Tekinay, A. B.; Guler, M. O. (Wiley, 2014-02-25)

Recent advances in understanding of cell-matrix interactions and the role of the extracellular matrix (ECM) in regulation of cellular behavior have created new perspectives for regenerative medicine. Supramolecular peptide ...

Biocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cells

Khalily, M. A.; Gulseren, G.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2015)

Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal ...

Biotinylated peptide nanofibers for modulating the immune response

Tohumeken, Şehmus (Bilkent University, 2016-06)

Despite the fact that vaccination eradicates many diseases, a broad variety of disorders cannot be treated using current vaccine development methods. In addition, it is difficult to rapidly develop new vaccines following ...

Cellular internalization of therapeutic oligonucleotides by peptide amphiphile nanofibers and nanospheres

Mumcuoglu, D.; S. Ekiz, M.; Gunay, G.; Tekinay, T.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2016-04)

Oligonucleotides are promising drug candidates due to the exceptionally high specificity they exhibit toward their target DNA and RNA sequences. However, their poor pharmacokinetic and pharmacodynamic properties, in ...

Chondrogenic differentiation of mesenchymal stem cells on glycosaminoglycan-mimetic peptide nanofibers

Yaylaci, S .U.; Sen, M.; Bulut, O.; Arslan, E.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2016)

Glycosaminoglycans (GAGs) are important extracellular matrix components of cartilage tissue and provide biological signals to stem cells and chondrocytes for development and functional regeneration of cartilage. Among their ...

Core-shell nanofibers of curcumin/cyclodextrin inclusion complex and polylactic acid: enhanced water solubility and slow release of curcumin

Aytac Z.; Uyar T. (Elsevier, 2017-02)

Core-shell nanofibers were designed via electrospinning using inclusion complex (IC) of model hydrophobic drug (curcumin, CUR) with cyclodextrin (CD) in the core and polymer (polylactic acid, PLA) in the shell (cCUR/HPβC ...