Browsing by Keywords "Molecular docking"

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Design, synthesis and anticancer/antiestrogenic activities of novel indole-benzimidazoles

Karadayı, F. Z.; Yaman, Murat; Kışla, M. M.; Keşküş, Ayşe G.; Konu, Özlen; Ateş Alagöz, Z. (Elsevier , 2020-05)

Indole-benzimidazoles have recently gained attention due to their antiproliferative and antiestrogenic effects. However, their structural similarities and molecular mechanisms shared with selective estrogen receptor ...
Evaluation of inhibitory effects of benzothiazole and 3-amino-benzothiazolium derivatives on DNA topoisomerase II by molecular modeling studies

Akı-Yalçın, E.; Ertan-Bolelli, T.; Taşkın-Tok, T.; Öztürk, Ö.; Ataei, S.; Özen, Çiğdem; Yıldız, I.; Yalçın, I. (Taylor and Francis, 2014)

There has been considerable interest in DNA topoisomerases over the last decade, as they have been shown to be one of the major cellular targets in anticancer drug development. Previously we synthesized some benzothiazole ...