Now showing items 1-12 of 12

    • Biosystems engineering of prokaryotes with tumor-killing capacities 

      Kalyoncu, E.; Olmez, T. T.; Ozkan, A. D.; Sarioglu, O. F. (Bentham Science Publishers Ltd., 2016)
      Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic ...
    • HER2 and proliferation of wound-induced breast carcinoma 

      Tez, M.; Göçmen, E.; Özçelik, T. (The Lancet Publishing, 2003-11-01)
    • Identification of the roles played by IKKε in hepatocellular and colorectal carcinogenesis 

      Kahya, Uğur (Bilkent University, 2018-07)
      Hepatocellular carcinomas (HCC) and colorectal carcinomas (CRC) are among the most common cancers worldwide with high mortality rates. While HCC affecting mostly underdeveloped countries, CRC is a disease that mainly occur ...
    • IKKs and tumor cell plasticity 

      Göktuna, S. I.; Diamanti, M. A.; Chau, T. L. (Wiley-Blackwell Publishing Ltd., 2018)
      Nuclear factor κB (NF-κB) transcription factors are the central hubs of signaling pathways connecting proinflammatory signals to cell survival, proliferation and cytokine production. In cancers, NF-κB signaling influences ...
    • Mechanistic pathways of malignancy in breast cancer stem cells 

      Yousefnia, S.; Forootan, F. S.; Forootan, S. S.; Esfahani, M. H. N.; Güre, Ali Osmay (Frontiers Media S.A., 2020-04-30)
      Breast cancer stem cells (BCSCs) are the minor population of breast cancer (BC) cells that exhibit several phenotypes such as migration, invasion, self-renewal, and chemotherapy as well as radiotherapy resistance. Recently, ...
    • Metastasis suppressor genes and proteins in non-melanoma skin cancers 

      Bozdoğan, Önder (Bilkent University, 2014-09)
      Skin cancers are the most common cancer in human population. They are practically divided into two major group; melanoma and non-melanoma skin cancer (NMSC). NMSC often refers to two common neoplasms; cutaneous squamous ...
    • MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours 

      Bulkowska, M.; Rybicka, A.; Senses, K. M.; Ulewicz, K.; Witt, K.; Szymanska, J.; Taciak, B.; Klopfleisch, R.; Hellmén, E.; Dolka, I.; Gure, A. O.; Mucha, J.; Mikow, M.; Gizinski, S.; Krol, M. (BioMed Central Ltd., 2017)
      Background: MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have ...
    • MicroRNas: master regulators of drug resistance, stemness and metastasis 

      Raza, U.; Zhang, J. D.; Şahin, Ö. (Springer Berlin Heidelberg, 2014-04)
      MicroRNAs (miRNAs) are 20-22 nucleotides long small non-coding RNAs that regulate gene expression post-transcriptionally. Last decade has witnessed emerging evidences of active roles of miRNAs in tumor development, ...
    • The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelialmesenchymal transition in breast cancer 

      Raza, U.; Saatci, O.; Uhlmann, S.; Ansari, S. A.; Eyüpoglu, E.; Yurdusev, E.; Mutlu, M.; Ersan, P. G.; Altundağ, M. K.; Zhang, J. D.; Dogan, H. T.; Güler, G.; Şahin, Ö. (Impact Journals LLC, 2016)
      Tumor cells develop drug resistance which leads to recurrence and distant metastasis. MicroRNAs are key regulators of tumor pathogenesis; however, little is known whether they can sensitize cells and block metastasis ...
    • Patrolling monocytes control tumor metastasis to the lung 

      Hanna, R. N.; Cekic, C.; Sag, D.; Tacke, R.; Thomas, G. D.; Nowyhed, H.; Herrley, E.; Rasquinha, N.; McArdle, S.; Wu, R.; Peluso, E.; Metzger, D.; Ichinose, H.; Shaked, I.; Chodaczek, G.; Biswas, S. K.; Hedrick, C. C. (American Association for the Advancement of Science, 2015)
      The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors ...
    • Prediction of prognosis and chemosensitivity in breast cancer 

      Akbar, Muhammad Waqas (Bilkent University, 2020-09)
      Breast cancer (BC) is responsible for the highest mortality and morbidity out of all the cancers in women which is primarily due to both inter and intra-tumoral molecular heterogeneity. This heterogeneity arises from ...
    • Systems-level analysis reveals multiple modulators of epithelial-mesenchymal transition and identifies DNAJB4 and CD81 as novel metastasis inducers in breast cancer 

      Üretmen-Kagıalı, Z. C.; Sanal, E.; Karayel, Ö.; Polat, A. N.; Saatci, Ö.; Ersan, Pelin Gülizar; Trappe, K.; Renard, B. Y.; Önder, T. T.; Tunçbağ, N.; Şahin, Özgür; Özlü, N. (American Society for Biochemistry and Molecular Biology, 2019)
      Epithelial-mesenchymal transition (EMT) is driven by complex signaling events that induce dramatic biochemical and morphological changes whereby epithelial cells are converted into cancer cells. However, the underlying ...