Now showing items 1-2 of 2

    • The role of IRE1 in metaflammation and atherosclerosis 

      Tufanlı, Özlem (Bilkent University, 2017-05)
      Chronic metabolic overloading of anabolic and catabolic organelles such as the endoplasmic reticulum (ER) and mitochondria is a major cause of inflammation in obesity. ER serves as a critical metabolic center for protein, ...
    • Targeting IRE1 with small molecules counteracts progression of atherosclerosis 

      Tufanli, O.; Akillilar, P. T.; Acosta-Alvear, D.; Kocaturk, B.; Onat, U. I.; Hamid, S. M.; Çimen, I.; Walter, P.; Weber, C.; Erbay, E. (National Academy of Sciences, 2017-01)
      Metaflammation, an atypical, metabolically induced, chronic lowgrade inflammation, plays an important role in the development of obesity, diabetes, and atherosclerosis. An important primer for metaflammation is the persistent ...