Browsing by Keywords "Mesenchymal stem cells"
Now showing items 1-14 of 14
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Chitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineering
(2012)The aim of this study is to develop an effective growth factor releasing scaffold-microsphere system for promoting periodontal tissue engineering. Bone morphogenetic protein-6 (BMP-6)-loaded alginate microspheres in narrow ... -
Chondrogenic differentiation of mesenchymal stem cells on glycosaminoglycan-mimetic peptide nanofibers
(American Chemical Society, 2016)Glycosaminoglycans (GAGs) are important extracellular matrix components of cartilage tissue and provide biological signals to stem cells and chondrocytes for development and functional regeneration of cartilage. Among their ... -
Contribution of toll-like receptors to mesenchymal stem cell differentiation and immunomodulation
(Bilkent University, 2010)characteristics along with several stem cell features such as lineage dependent differentiation and self-renewal capacity. MSCs are known to induce immunomodulatory activity and homing capacity to damaged tissue sites. ... -
Development and characterization of peptide nanofibers for cartilage regeneration
(Bilkent University, 2015-09)Articular cartilage is a tissue that is continuously exposed to cyclical compressive stresses, but exhibits no capacity for self-healing following trauma. Cartilage has a dense extracellular matrix that is sparsely ... -
Effect of double growth factor release on cartilage tissue engineering
(2013)The effects of double release of insulin-like growth factor I (IGF-I) and growth factor β1 (TGF-β1) from nanoparticles on the growth of bone marrow mesenchymal stem cells and their differentiation into cartilage cells were ... -
The Effect of estrogen on bone Marrow-Derived rat mesenchymal stem cell maintenance: inhibiting apoptosis through the expression of bcl-x l and bcl-2
(Springer Science+Business Media, 2012)Mesenchymal Stem Cells (MSCs) have high therapeutic value for regenerative medicine and tissue engineering due to their differentiation potential and non-immunogenic characteristics. They are also considered as an effective ... -
The effect of telomerase template antagonist GRN163L on Bone-Marrow-Derived rat mMesenchymal stem cells is reversible and associated with altered expression of cyclin d1, cdk4 and cdk6
(Springer Science+Business Media, 2010)Telomerase activity is essential for the continued growth and survival of malignant cells, therefore inhibition of this activity presents an attractive target for anti-cancer therapy. The telomerase inhibitor GRN163L, was ... -
Immunomodulatory potential of human umbilical cord tissue-derived mesenchymal stromal cell (UCX®) exosomes in combination with immunosuppressive “A151” oligodeoxynucleotide
(Bilkent University, 2019-07)Mesenchymal stromal or stem cells (MSCs) modulate immune responses apart from their regenerative capacities. Accumulating evidence suggests that MSCs exert their paracrine effects through extracellular vesicles known as ... -
Liver regeneration : potential roles of mesenchymal stem cells and toll like receptors
(Bilkent University, 2008)Akçalı -
Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infection
(Scientific and Technical Research Council of Turkey, 2020)Discovery of novel and broad-acting immunomodulators is of critical importance for the prevention and treatment of disorders occurring due to overexuberant immune responseincluding SARS-CoV-2 triggered cytokine storm leading ... -
Mesenchymal stem cell mechanics on osteoinductive peptide nanofibers
(Bilkent University, 2017-07)In this thesis, changes in Young's modulus of mesenchymal stem cells (MSCs) were investigated during their osteogenic differentiation on bioactive peptide nanofibers that bear triple glutamic acid sequence (EEE), a ... -
Nanomechanical characterization of osteogenic differentiation of mesenchymal stem cells on bioactive peptide nanofiber hydrogels
(Wiley-VCH Verlag, 2017-08)Stem cell differentiation is known to be influenced by the mechanical properties of the surrounding extracellular matrix (ECM); however, little is known about the mechanical phenotypes of differentiating stem cells within ... -
Preparation and characterization of poly(hydroxyethyl methacrylate-co-poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells
(Hangug Gobunja Haghoi, 2010-12-02)This study examined the effects of the surface properties of the materials, such as the hydroxyl, methyl and amino groups, on rat bone marrow derived Mesenchymal Stem Cell (MSC) seeding. A series of hydrogels were prepared ... -
Timing of induction of cardiomyocyte differentiation for in vitro cultured mesenchymal stem cells: a perspective for emergencies
(NRC Research Press, 2009)Mesenchymal stem cells (MSCs) have the capacity to differentiate into osteoblasts, chondrocytes, adipocytes, myocytes, and cardiomyocytes. Several established methods are presently available for in vitro isolation of MSCs ...
