Browsing by Keywords "Mediator complex"
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POLR2A/RPB1 subunit of RNA polymerase II interacts with NTDMED14 containing core mediator complex to facilitate basal and activator driven transcription
(Bilkent University, 2020-06)The Metazoan Mediator is a 2-MDa protein complex that consist of 30 subunits, most of which are evolutionarily conserved from yeast to humans8. The maintenance and regulation of the cell is dependent on spatiotemporal ... -
Reconstitution of the partial tail module of the human mediator complex
(Bilkent University, 2021-09)RNA Polymerase II (Pol II) regulates and maintains every aspect of the cell through the act of transcription of protein coding genes. Transcription of protein coding genes depends on extrinsic and intrinsic signals to the ... -
The role of mediator complex in tamoxifen resistance of ER-positive breast cancer
(Bilkent University, 2022-01)Breast cancer is the most prevalent cancer type and the leading cause of cancer mortality among women worldwide. Estrogen receptor-positive (ER+) breast cancer is the most common clinical subtype with an incidence rate ...
