Now showing items 1-5 of 5

    • Genetics and epigenetics of liver cancer 

      Özen, Çiğdem; Yıldız, Gökhan; Dağcan, Alper Tunga; Çevik, Dilek; Örs, Ayşegül; Keleş, Umut; Topel, Hande; Öztürk, Mehmet (Elsevier B.V., 2013)
      Hepatocellular carcinoma (HCC) represents a major form of primary liver cancer in adults. Chronic infections with hepatitis B (HBV) and C (HCV) viruses and alcohol abuse are the major factors leading to HCC. This deadly ...
    • Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular carcinoma 

      Acun T.; Terzioǧlu-Kara, E.; Konu, O.; Ozturk, M.; Yakicier, M. C. (Elsevier, 2010)
      Loss of function of the p53 protein, which may occur through a range of molecular events, is critical in hepatocellular carcinoma (HCC) evolution. MDM2, an oncogene, acts as a major regulator of the p53 protein. A polymorphism ...
    • p53 mutation as a source of aberrant β-catenin accumulation in cancer cells 

      Cagatay, T.; Ozturk, M. (2002)
      β-catenin is involved in both cell-cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and TCF/LEF transcription factors, respectively. Cytoplasmic/nuclear levels ...
    • PPAR-alpha L162V polymorphism in human hepatocellular carcinoma 

      Koytak, E.S.; Mizrak, D.; Bektaş, M.; Verdi H.; Ergül, A.A.; Idilman, R.; Çinar, K.; Yurdaydin, C.; Ersöz, S.; Karayalçin, K.; Uzunalimoǧlu Ö.; Bozkaya H. (2008)
      Background/aims: Several lines of evidence suggest that peroxisome proliferator-activated receptor alpha may be involved in hepatocarcinogenesis. L162V polymorphism of the peroxisome proliferator-activated receptor alpha ...
    • SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation 

      Acun, T.; Oztas, E.; Yagci, T.; Yakicier, M.C. (2011)
      Background: Smad interacting protein-1 is a transcription factor that is implicated in transforming growth factor-β/bone morphogenetic protein signaling and a repressor of E-cadherin and human telomerase reverse transcriptase. ...