Now showing items 1-6 of 6

    • A hybrid nanofiber matrix to control the survival and maturation of brain neurons 

      Sur, S.; Pashuck, E. T.; Guler, M. O.; Ito, M.; Stupp, S. I.; Launey, T. (Elsevier BV, 2012)
      Scaffold design plays a crucial role in developing graft-based regenerative strategies, especially when intended to be used in a highly ordered nerve tissue. Here we describe a hybrid matrix approach, which combines the ...
    • Investigation of spontaneous differentiation of neural stem cells on synthetic scaffolds 

      Uyan, İdil (Bilkent University, 2017-08)
      Despite the increasing incidents of brain injuries and neurodegenerative diseases, a definitive clinical therapy for these conditions has not been found yet. Nervous system injuries result in loss of neural cells, causing ...
    • Investigation of the effects of bioactive peptide nanofibers on acute muscle injury regeneration 

      Eren Çimenci, Çağla (Bilkent University, 2016-11)
      Skeletal muscle constitutes a large part of the human body. It is a hierarchically organized heterogeneous tissue and is composed of muscle fiber bundles, muscle fibers, myofibrils and myofilaments. Since muscle cells are ...
    • Laminin mimetic peptide nanofibers regenerate acute muscle defect 

      Cimenci, C. E.; Uzunalli, G.; Uysal, O.; Yergoz, F.; Umay, E. K.; Guler, M. O.; Tekinay, A. B. (Acta Materialia Inc, 2017)
      Skeletal muscle cells are terminally differentiated and require the activation of muscle progenitor (satellite) cells for their regeneration. There is a clinical need for faster and more efficient treatment methods for ...
    • Recessive LAMC3 mutations cause malformations of occipital cortical development 

      Barak, T.; Kwan, K. Y.; Louvi, A.; Demirbilek, V.; Saygi, S.; Tüysüz, B.; Choi, M.; Boyaci, H.; Doerschner, K.; Zhu, Y.; Kaymakçalan, H.; Yilmaz, S.; Bakircioglu, M.; Çağlayan, A. O.; Öztürk, A.K.; Yasuno, K.; Brunken W. J.; Atalar, E.; Yalçnkaya, C.; Dinçer, A.; Bronen, R. A.; Mane, S.; Özçelik, T.; Lifton, R. P.; Šestan, N.; Bilgüvar, K.; Günel, M. (Nature Publishing Group, 2011-05-15)
      The biological basis for regional and inter-species differences in cerebral cortical morphology is poorly understood. We focused on consanguineous Turkish families with a single affected member with complex bilateral ...
    • Three-Dimensional Laminin Mimetic Peptide Nanofiber Gels for In Vitro Neural Differentiation 

      Gunay, G.; Sever, M.; Tekinay, A. B.; Guler, M. O. (Wiley-VCH Verlag, 2017)
      The extracellular matrix (ECM) provides biochemical signals and structural support for cells, and its functional imitation is a fundamental aspect of biomaterial design for regenerative medicine applications. The stimulation ...