Browsing by Keywords "LL37"

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Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity

Kahraman, T.; Gucluler, G.; Simsek, I.; Yagci, F. C.; Yildirim, M.; Ozen, C.; Dinc, A.; Gursel, M.; Ikromzoda, L.; Sutlu, T.; Gay, S.; Gursel, I. (Taylor and Francis, 2017-02)

Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived ...
Immunotherapeutic action of extracellular vesicles and effects of TLR signaling to immune dysfunction of SCI patients

Güçlüler, Gözde (Bilkent University, 2017-03)

The primary aim of this thesis is to extend the breadth of in vivo application of externally loaded exosomes as prophylactic or therapeutic carriers against disease treatment. Exosomes are secreted from all cells and ...