Now showing items 1-10 of 10

    • Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds 

      Uzunalli, G.; Mammadov R.; Yesildal, F.; Alhan, D.; Ozturk, S.; Ozgurtas, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2017)
      Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of ...
    • Biocompatibility studies on lanthanum oxide nanoparticles 

      Brabu, B.; Haribabu, S.; Revathy, M.; Anitha, S.; Thangapandiyan, M.; Navaneethakrishnan, K. R.; Gopalakrishnan, C.; Murugan, S. S.; Kumaravel, T. S. (Royal Society of Chemistry, 2015)
      Lanthanum oxide nanoparticles (LONP), a rare earth metal oxide, have unique properties that make them a suitable candidate for several biomedical applications. We investigated certain key in vitro and in vivo biocompatibility ...
    • A glycosaminoglycan mimetic peptide nanofiber gel as an osteoinductive scaffold 

      Tansik, G.; Kilic, E.; Beter, M.; Demiralp, B.; K.Sendur, G.; Can, N.; Ozkan, H.; Ergul, E.; Guler, M. O.; Tekinay, A. B. (Royal Society of Chemistry, 2016)
      Biomineralization of the extracellular matrix (ECM) plays a crucial role in bone formation. Functional and structural biomimetic native bone ECM components can therefore be used to change the fate of stem cells and induce ...
    • Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury 

      Yergoz, F.; Hastar, N.; Cimenci, C. E.; Ozkan, A. D.; Guler, M. O.; Tekinay, A. B.; Tekinay, T.; Guler, M. O. (Elsevier Ltd, 2017)
      Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, ...
    • Implantable microelectromechanical sensors for diagnostic monitoring and post-surgical prediction of bone fracture healing 

      McGilvray, K. C.; Ünal, E.; Troyer, K. L.; Santoni, B. G.; Palmer, R. H.; Easley, J. T.; Demir, Hilmi Volkan; Puttlitz, C. M. (John Wiley and Sons Inc., 2015)
      The relationship between modern clinical diagnostic data, such as from radiographs or computed tomography, and the temporal biomechanical integrity of bone fracture healing has not been well-established. A diagnostic tool ...
    • Inhibition of VEGF mediated corneal neovascularization by anti-angiogenic peptide nanofibers 

      Senturk, B.; Cubuk, M. O.; Ozmen, M. C.; Aydin B.; Guler, M. O.; Tekinay, A. B. (Elsevier, 2016-11)
      Atypical angiogenesis is one of the major symptoms of severe eye diseases, including corneal neovascularization, and the complex nature of abnormal vascularization requires targeted methods with high biocompatibility. The ...
    • Injectable in situ forming microparticles: A novel drug delivery system 

      Yapar, E. A.; Inal, Ö.; Özkan, Y.; Baykara, T. (2012)
      Pharmaceutical formulation research has recently been focusing on delivery systems which provide long therapeutic effects and reduced side effects, and involving simplified production stages and facilitated application ...
    • Laminin mimetic peptide nanofibers regenerate acute muscle defect 

      Cimenci, C. E.; Uzunalli, G.; Uysal, O.; Yergoz, F.; Umay, E. K.; Guler, M. O.; Tekinay, A. B. (Acta Materialia Inc, 2017)
      Skeletal muscle cells are terminally differentiated and require the activation of muscle progenitor (satellite) cells for their regeneration. There is a clinical need for faster and more efficient treatment methods for ...
    • Patrolling monocytes control tumor metastasis to the lung 

      Hanna, R. N.; Cekic, C.; Sag, D.; Tacke, R.; Thomas, G. D.; Nowyhed, H.; Herrley, E.; Rasquinha, N.; McArdle, S.; Wu, R.; Peluso, E.; Metzger, D.; Ichinose, H.; Shaked, I.; Chodaczek, G.; Biswas, S. K.; Hedrick, C. C. (American Association for the Advancement of Science, 2015)
      The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors ...
    • Targeting IRE1 with small molecules counteracts progression of atherosclerosis 

      Tufanli, O.; Akillilar, P. T.; Acosta-Alvear, D.; Kocaturk, B.; Onat, U. I.; Hamid, S. M.; Çimen, I.; Walter, P.; Weber, C.; Erbay, E. (National Academy of Sciences, 2017-01)
      Metaflammation, an atypical, metabolically induced, chronic lowgrade inflammation, plays an important role in the development of obesity, diabetes, and atherosclerosis. An important primer for metaflammation is the persistent ...