Now showing items 1-6 of 6

    • Immunomodulatory effects of exosomes: promising candidates in immunotherapy 

      Kılgöz, Havva Özgen (Bilkent University, 2018-08)
      Exosomes are type of extracellular vesicles secreted from almost all cell types and carry numerous biological molecules such as nucleic acids, protein and lipids. They mediate many cellular processes including cellular ...
    • Immunomodulatory effects of TLR ligands and polysaccharide combinations : strategies to augment innate immune response 

      Tincer, Gizem (Bilkent University, 2007)
      Microbial infection initiates multiple TLR ligand mediated signaling cascade on innate immune cells. While some TLRs trigger a Th1 biased immune activation, others may lead to a Th2 dominant immune response. Extracellular ...
    • Induction of potent protection against acute and latent herpes simplex virus infection in mice vaccinated with dendritic cells 

      Ghasemi, M.; Erturk, M.; Buruk, K.; Sonmez, M. (2013)
      Background aims. Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system and have been under intense study with regard to their use in immunotherapy against cancer and infectious disease ...
    • Patrolling monocytes control tumor metastasis to the lung 

      Hanna, R. N.; Cekic, C.; Sag, D.; Tacke, R.; Thomas, G. D.; Nowyhed, H.; Herrley, E.; Rasquinha, N.; McArdle, S.; Wu, R.; Peluso, E.; Metzger, D.; Ichinose, H.; Shaked, I.; Chodaczek, G.; Biswas, S. K.; Hedrick, C. C. (American Association for the Advancement of Science, 2015)
      The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors ...
    • Purinergic regulation of the immune system 

      Cekic, C.; Linden, J. (Nature Publishing Group, 2016)
      Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling molecules by activating cell-surface ...
    • TLR ligand loaded exosome mediated immunotherapy of established mammary Tumor in mice 

      Yıldırım, Muzaffer; Yıldırım, Tuğçe Canavar; Turay, Nilsu; Bildik, Tuğçe; İbibik, Bilgehan; Evcili, İrem; Ersan, Pelin Gülizar; Tokat, Ünal M.; Sahin, Ö.; Gürsel, İhsan (Elsevier BV, 2021-11)
      Tumor-derived exosomes (TEXs) could be harnessed as an immunotherapeutic cancer vaccine. These nanovesicles are inherently possesses rich tumor antigen reservoirs. Due to their undesirable features such as poor or limited ...