Now showing items 1-9 of 9

    • The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity 

      Mumcuoglu, M.; Bagislar, S.; Yuzugullu, H.; Alotaibi, H.; Senturk, S.; Telkoparan, P.; Gur-Dedeoglu, B.; Cingoz, B.; Bozkurt, B.; Tazebay, U. H.; Yulug, I. G.; Akcali, K. C.; Ozturk, M. (PUBLIC LIBRARY OF SCIENCE, 2010)
      Background Breast cancer is a remarkably heterogeneous disease. Luminal, basal-like, "normal-like", and ERBB2+ subgroups were identified and were shown to have different prognoses. The mechanisms underlying this heterogeneity ...
    • Age related alterations of adult neurogenesis and astrocytes in Zebrafish (Danio Rerio) 

      Ardıç, Narin Ilgım (Bilkent University, 2019-09)
      Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. In order to identify appropriate interventions to change the course of brain aging and age-related neurological ...
    • Bioactive self-assembled peptide nanofibers for corneal stroma regeneration 

      Uzunalli, G.; Soran, Z.; Erkal, T. S.; Dagdas, Y. S.; Dinc, E.; Hondur, A. M.; Bilgihan, K.; Aydin B.; Guler, M. O.; Tekinay, A. B. (Elsevier, 2014)
      Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential ...
    • Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma 

      Bozdogan, O.; Yulug, I. G.; Vargel, I.; Cavusoglu, T.; Karabulut, A. A.; Karahan, G.; Sayar, N. (Wiley-Blackwell Publishing Ltd., 2015)
      Background: Basal cell carcinomas (BCCs) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of the ...
    • Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury 

      Yergoz, F.; Hastar, N.; Cimenci, C. E.; Ozkan, A. D.; Guler, M. O.; Tekinay, A. B.; Tekinay, T.; Guler, M. O. (Elsevier Ltd, 2017)
      Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, ...
    • Metastasis suppressor proteins in cutaneous squamous cell carcinoma 

      Bozdogan, O.; Vargel, I.; Cavusoglu, T.; Karabulut, A. A.; Karahan, G.; Sayar, N.; Atasoy, P.; Yulug, I. G. (Elsevier, 2016-07)
      Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. ...
    • Mutations in RAD21 disrupt regulation of apob in patients with chronic intestinal pseudo-obstruction 

      Bonora, E.; Bianco, F.; Cordeddu, L.; Bamshad, M.; Francescatto, L.; Dowless, D.; Stanghellini, V.; Cogliandro, R. F.; Lindberg, G.; Mungan, Z.; Cefle, K.; Ozcelik, T.; Palanduz, S.; Ozturk, S.; Gedikbasi, A.; Gori, A.; Pippucci, T.; Graziano, C.; Volta, U.; Caio, G.; Barbara, G.; D'Amato, M.; Seri, M.; Katsanis, N.; Romeo, G.; De Giorgio, R. (W.B. Saunders, 2015)
      Background Aims Chronic intestinal pseudo-obstruction (CIPO) is characterized by severe intestinal dysmotility that mimics a mechanical subocclusion with no evidence of gut obstruction. We searched for genetic variants ...
    • Naringenin inhibits neointimal hyperplasia following arterial reconstruction with interpositional vein graft 

      Cayci, C.; Wahlquist, T. C.; Seckin, S. I.; Ozcan, V.; Tekinay, A. B.; Martens, T. P.; Oz, M. C.; Ascherman, J. A. (Lippincott Williams & Wilkins, 2010)
      Vessels respond to injury by a healing process that includes the development of neointima. Stenosis secondary to neointima formation is the main cause of failure following arterial reconstructions. Vessel wall homeostasis ...
    • Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays 

      Oztas, E.; Avci, M. E.; Ozcan, A.; Sayan, A. E.; Tulchinsky, E.; Yagci, T. (Elsevier, 2010)
      Smad-interacting protein 1 (SIP1, also known as ZEB2) represses the transcription of E-cadherin and mediates epithelial-mesenchymal transition in development and tumor metastasis. Due to the lack of human SIP1-specific ...