Now showing items 1-20 of 126

    • 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1 

      Tunçer, S.; Keşküş, A. G.; Çolakoğlu, M.; Çimen, I.; Yener, C.; Konu, Ö.; Banerjee, S. (Elsevier, 2017-11)
      15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been ...
    • Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism? 

      Irmak, M. B.; Ince, G.; Ozturk, M.; Cetin Atalay, R. (American Association for Cancer Research, 2003)
      Selenium is essential to human health, and its deficiency is associated with different diseases including liver necrosis. Selenium is protective against viral hepatitis and hepatocellular carcinoma (HCC). The underlying ...
    • Adjuvant autologous melanoma vaccine for macroscopic stage III disease: survival, biomarkers, and improved response to CTLA-4 blockade 

      Lotem, M.; Merims, S.; Frank, S.; Hamburger, T.; Nissan, A.; Kadouri, L.; Cohen, J.; Straussman, R.; Eisenberg, G.; Frankenburg, S.; Carmon, E.; Alaiyan, B.; Shneibaum, S.; Ayyildiz, Z. O.; Isbilen, M.; Senses, K. M.; Ron, I.; Steinberg, H.; Smith, Y.; Shiloni, E.; Gure, A. O.; Peretz, T. (Hindawi Limited, 2016)
      Background. There is not yet an agreed adjuvant treatment for melanoma patients with American Joint Committee on Cancer stages III B and C. We report administration of an autologous melanoma vaccine to prevent disease ...
    • Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio) 

      Karoglu, E. T.; Halim, D. O.; Erkaya, B.; Altaytas, F.; Arslan-Ergul, A.; Konu, O.; Adams, M. M. (Elsevier, 2017-06)
      The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ...
    • Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias 

      Akyerli, C. B.; Özbek, U.; Aydin-Sayitoǧlu, M.; Sirma, S.; Özçelik, T. (Springer, 2003)
      [No abstract available]
    • Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases 

      Chabchoub, G.; Uz, E.; Maalej, A.; Mustafa, C. A.; Rebai, A.; Mnif, M.; Bahloul, Z.; Farid, N. R.; Ozcelik, T.; Ayadi, H. (BioMed Central, 2009)
      Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. ...
    • Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation 

      Ravens, U.; Katircioglu-Öztürk, D.; Wettwer, E.; Christ, T.; Dobrev, D.; Voigt, N.; Poulet, C.; Loose, S.; Simon, J.; Stein, A.; Matschke, K.; Knaut, M.; Oto, E.; Oto, A.; Güvenir, H. A. (Springer, 2015)
      Ex vivo recorded action potentials (APs) in human right atrial tissue from patients in sinus rhythm (SR) or atrial fibrillation (AF) display a characteristic spike-and-dome or triangular shape, respectively, but variability ...
    • Atomic force microscopy for the investigation of molecular and cellular behavior 

      Ozkan A.D.; Topal, A. E.; Dana, A.; Guler, M. O.; Tekinay, A. B. (Elsevier, 2016-10)
      The present review details the methods used for the measurement of cells and their exudates using atomic force microscopy (AFM) and outlines the general conclusions drawn by the mechanical characterization of biological ...
    • Attributed relational graphs for cell nucleus segmentation in fluorescence microscopy images 

      Arslan, S.; Ersahin, T.; Cetin-Atalay, R.; Gunduz-Demir, C. (IEEE, 2013)
      More rapid and accurate high-throughput screening in molecular cellular biology research has become possible with the development of automated microscopy imaging, for which cell nucleus segmentation commonly constitutes ...
    • Bioactive self-assembled peptide nanofibers for corneal stroma regeneration 

      Uzunalli, G.; Soran, Z.; Erkal, T. S.; Dagdas, Y. S.; Dinc, E.; Hondur, A. M.; Bilgihan, K.; Aydin B.; Guler, M. O.; Tekinay, A. B. (Elsevier, 2014)
      Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential ...
    • Biological properties of extracellular vesicles and their physiological functions 

      Yáñez-Mó, M.; Siljander, P. R. M.; Andreu, Z.; Zavec, A. B.; Borràs, F. E.; Buzas, E. I.; Buzas, K.; Casal, E.; Cappello, F.; Carvalho, J.; Colás, E.; Cordeiro-Da, S. A.; Fais, S.; Falcon-Perez, J. M.; Ghobrial, I. M.; Giebel, B.; Gimona, M.; Graner, M.; Gursel, I.; Gursel, M.; Heegaard, N. H. H.; Hendrix, A.; Kierulf, P.; Kokubun, K.; Kosanovic, M.; Kralj-Iglic, V.; Krämer-Albers, E. M.; Laitinen, S.; Lässer, C.; Lener, T.; Ligeti, E.; Line, A.; Lipps, G.; Llorente, A.; Lötvall, J.; Manček-Keber, M.; Marcilla, A.; Mittelbrunn, M.; Nazarenko, I.; Nolte-'t Hoen, E. N. M.; Nyman, T. A.; O'Driscoll, L.; Olivan, M.; Oliveira, C.; Pállinger, E.; Del Portillo, H. A.; Reventós, J.; Rigau, M.; Rohde, E.; Sammar, M.; Sánchez-Madrid, F.; Santarém, N.; Schallmoser, K.; Ostenfeld, M. S.; Stoorvogel, W.; Stukelj, R.; Grein V. D. S.G.; Helena,ü V. M.; Wauben, M. H. M.; De Wever, O. (Taylor & Francis, 2015)
      In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and ...
    • Biosystems engineering of prokaryotes with tumor-killing capacities 

      Kalyoncu, E.; Olmez, T. T.; Ozkan, A. D.; Sarioglu, O. F. (Bentham Science Publishers Ltd., 2016)
      Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic ...
    • BRAPH: A graph theory software for the analysis of brain connectivity 

      Mijalkov, M.; Kakaei, E.; Pereira, J. B.; Westman, E.; Volpe, G. (Public Library of Science, 2017)
      The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts ...
    • Carving event and episodic memory at their Joints 

      Keven, Nazım (Cambridge University Press, 2018)
      Mahr & Csibra (M&C) argue that event and episodic memories share the same scenario construction process. I think this way of carving up the distinction throws the baby out with the bathwater. If there is a substantive ...
    • Cellular internalization of therapeutic oligonucleotides by peptide amphiphile nanofibers and nanospheres 

      Mumcuoglu, D.; S. Ekiz, M.; Gunay, G.; Tekinay, T.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2016-04)
      Oligonucleotides are promising drug candidates due to the exceptionally high specificity they exhibit toward their target DNA and RNA sequences. However, their poor pharmacokinetic and pharmacodynamic properties, in ...
    • Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity 

      Kahraman, T.; Gucluler, G.; Simsek, I.; Yagci, F. C.; Yildirim, M.; Ozen, C.; Dinc, A.; Gursel, M.; Ikromzoda, L.; Sutlu, T.; Gay, S.; Gursel, I. (Taylor and Francis, 2017-02)
      Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived ...
    • Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease 

      Gül, A.; Özbek, U.; Öztürk, C.; Inanç, M.; Koniçe, M.; Özçelik, T. (Oxford University Press, 1996)
      We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in ...
    • Colon cancer associated transcript-1 (CCAT1) expression in adenocarcinoma of the stomach 

      Mizrahi, I.; Mazeh, H.; Grinbaum, R.; Beglaibter, N.; Wilschanski, M.; Pavlov, V.; Adileh, M.; Stojadinovic, A.; Avital, I.; Gure, A. O.; Halle, D.; Nissan, A. (Ivyspring International Publisher, 2015)
      Background: Long non-coding RNAs (lncRNAs) have been shown to have functional roles in cancer biology and are dys-regulated in many tumors. Colon Cancer Associated Transcript -1 (CCAT1) is a lncRNA, previously shown to be ...
    • A color and shape based algorithm for segmentation of white blood cells in peripheral blood and bone marrow images 

      Arslan, S.; Ozyurek, E.; Gunduz Demir, C. (John Wiley & Sons, Inc., 2014)
      Computer-based imaging systems are becoming important tools for quantitative assessment of peripheral blood and bone marrow samples to help experts diagnose blood disorders such as acute leukemia. These systems generally ...
    • A combined ULBP2 and SEMA5A expression signature as a prognostic and predictive biomarker for colon cancer 

      Demirkol, S.; Gomceli, I.; Isbilen, M.; Dayanc, B. E.; Tez, M.; Bostanci, E. B.; Turhan, N.; Akoglu, M.; Ozyerli, E.; Durdu, S.; Konu, O.; Nissan, A.; Gonen, M.; Gure, A. O. (Ivyspring International Publisher, 2017)
      Background: Prognostic biomarkers for cancer have the power to change the course of disease if they add value beyond known prognostic factors, if they can help shape treatment protocols, and if they are reliable. The aim ...