Browsing by Keywords "Glycosaminoglycan"

Angiogenic peptide nanofibers repair cardiac tissue defect after myocardial infarction

Rufaihah, A. J.; Yasa, I. C.; Ramanujam, V. S.; Arularasu, S. C.; Kofidis, T.; Güler, Mustafa O.; Tekinay, A. B. (Acta Materialia Inc, 2017)

Myocardial infarction remains one of the top leading causes of death in the world and the damage sustained in the heart eventually develops into heart failure. Limited conventional treatment options due to the inability ...

Bioactive glycopeptide nanofibers for tissue regeneration applications

Çalışkan, Özüm Şehnaz. (Bilkent University, 2016-05)

Natural extracellular matrix (ECM) is rich in glycopeptides and glycosaminoglycans, which function in controlling cellular processes. In this thesis, glycopeptide molecules that mimic natural glycopeptides and glycosaminoglycans ...

Chondrogenic differentiation of mesenchymal stem cells on glycosaminoglycan-mimetic peptide nanofibers

Yaylaci, S .U.; Sen, M.; Bulut, O.; Arslan, E.; Güler, Mustafa O.; Tekinay, A. B. (American Chemical Society, 2016)

Glycosaminoglycans (GAGs) are important extracellular matrix components of cartilage tissue and provide biological signals to stem cells and chondrocytes for development and functional regeneration of cartilage. Among their ...

A glycosaminoglycan mimetic peptide nanofiber gel as an osteoinductive scaffold

Tansik, G.; Kilic, E.; Beter, M.; Demiralp, B.; K.Sendur, G.; Can, N.; Ozkan, H.; Ergul, E.; Güler, Mustafa O.; Tekinay, A. B. (Royal Society of Chemistry, 2016)

Biomineralization of the extracellular matrix (ECM) plays a crucial role in bone formation. Functional and structural biomimetic native bone ECM components can therefore be used to change the fate of stem cells and induce ...

Glycosaminoglycan mimetric peptide nanofibers promote mineralization by osteogenic cells

Kocabey, Samet; Ceylan, Hakan; Tekinay, Ayse B.; Güler, Mustafa O. (Elsevier, 2013)

Bone tissue regeneration is accomplished by concerted regulation of protein-based extracellular matrix components, glycosaminoglycans (GAGs) and inductive growth factors. GAGs constitute a significant portion of the ...

Glycosaminoglycan-Mimetic Signals Direct the Osteo/Chondrogenic Differentiation of Mesenchymal Stem Cells in a Three-Dimensional Peptide Nanofiber Extracellular Matrix Mimetic Environment

Arslan, E.; Güler, Mustafa O.; Tekinay, A. B. (American Chemical Society, 2016-02)

Recent efforts in bioactive scaffold development focus strongly on the elucidation of complex cellular responses through the use of synthetic systems. Designing synthetic extracellular matrix (ECM) materials must be based ...

Multivalent presentation of cationic peptides on supramolecular nanofibers for antimicrobial activity

Beter, M.; Kara, H. K.; Topal, A. E.; Dana, A.; Tekinay, A. B.; Güler, Mustafa O. (American Chemical Society, 2017)

Noncovalent and electrostatic interactions facilitate the formation of complex networks through molecular self-assembly in biomolecules such as proteins and glycosaminoglycans. Self-assembling peptide amphiphiles (PA) are ...

Neuroactive peptide nanofibers for regeneration of spinal cord after injury

Sever-Bahçekapılı, Melike; Yılmaz, Canelif; Demirel, A.; Kilinc, M. C.; Dogan, I.; Caglar, Y. S.; Guler, M. O.; Tekinay, Ayşe Begüm (Wiley-VCH Verlag GmbH & Co. KGaA, 2020-10-11)

The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellular regeneration and functional recovery. Promising SCI treatments use biomaterial scaffolds, which ...