Browsing by Keywords "Extracellular matrix"
Now showing items 1-16 of 16
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Affinity of glycopeptide nanofibers to growth factors and their effects on cells
(Bilkent University, 2017-09)The development of scaffolds for growth factor delivery is a promising approach for tissue regeneration applications due to their crucial roles during regeneration. Growth factor secretion and interactions with glycosaminoglycans ... -
Bioactive glycopeptide nanofibers for tissue regeneration applications
(Bilkent University, 2016-05)Natural extracellular matrix (ECM) is rich in glycopeptides and glycosaminoglycans, which function in controlling cellular processes. In this thesis, glycopeptide molecules that mimic natural glycopeptides and glycosaminoglycans ... -
Bioactive peptide nanofibers for bone tissue regeneration
(Bilkent University, 2017-06)Replacement and repair of bone tissue that is lost due to fractures, tumor resection, degenerative diseases and infections still remain major clinical challenges. Autografting, allografting and xenografting are the current ... -
Bioactive peptide nanofibers for acceleration of burn wound healing
(Bilkent University, 2017-05)Burn injuries are one of the most typical types of trauma worldwide, and the unique physiology of burn injuries requires the use of specialized therapeutic materials for treatment and makes the development of such materials ... -
Bioactive peptide nanofibers for tissue regeneration
(Bilkent University, 2016-01)Defects in the tissues or organs caused by trauma or diseases can have detrimental effects on all aspects of patients’ life quality. During the last three decades, considerable developments have been made in tissue engineering ... -
Chondrogenic differentiation of mesenchymal stem cells on glycosaminoglycan-mimetic peptide nanofibers
(American Chemical Society, 2016)Glycosaminoglycans (GAGs) are important extracellular matrix components of cartilage tissue and provide biological signals to stem cells and chondrocytes for development and functional regeneration of cartilage. Among their ... -
Design and development of ecm-inspired peptidebased nanostructures for bioengineering and biomedicine
(Bilkent University, 2017-08)Advances in understanding of cell-matrix interactions and the regulation of cellular behaviors through nanobiotechnological tools have presented new perspectives for regenerative medicine. Peptide amphiphiles have been ... -
Development of peptide based materials as a synthetic scaffold to mimic extracellular matrix
(Bilkent University, 2017-07)Biomaterials obtained through self-assembling process of peptide amphiphile (PA) molecules provide great potential to introduce new therapeutic approaches in regenerative medicine through mimicking the natural environments ... -
Glycosaminoglycan-Mimetic Signals Direct the Osteo/Chondrogenic Differentiation of Mesenchymal Stem Cells in a Three-Dimensional Peptide Nanofiber Extracellular Matrix Mimetic Environment
(American Chemical Society, 2016-02)Recent efforts in bioactive scaffold development focus strongly on the elucidation of complex cellular responses through the use of synthetic systems. Designing synthetic extracellular matrix (ECM) materials must be based ... -
Nanomaterials for neural regeneration
(John Wiley & Sons, 2016-03-11)The central nervous system (CNS) consists of a dense network of cells leaving a smaller volume for the extracellular matrix (ECM) components (10‐20% for the brain unlike most other tissues (Cragg, 1979)). The reaction of ... -
Neural ECM mimetics
(Elsevier, 2014)The consequence of numerous neurological disorders is the significant loss of neural cells, which further results in multilevel dysfunction or severe functional deficits. The extracellular matrix (ECM) is of tremendous ... -
Peripheral nerve regeneration by synthetic peptide nanofibers
(Bilkent University, 2016-09)The peripheral nervous system (PNS) has a complex structure that consists of high numbers of nerve cells and communication networks between the central nervous system and the body parts. Unlike the central nervous system, ... -
Self-assembled peptide amphiphile nanofibers and PEG composite hydrogels as tunable ECM mimetic microenvironment
(American Chemical Society, 2015)(Figure Presented). Natural extracellular matrix (ECM) consists of complex signals interacting with each other to organize cellular behavior and responses. This sophisticated microenvironment can be mimicked by advanced ... -
Three dimensional glycosaminoglycan mimetic peptide amphiphile hydrogels for regenerative medicine applications
(Bilkent University, 2015-05)Defects and impairments of tissues or organs affect millions of people, resulting in considerable losses in workforce and life quality. The treatment of major tissue injuries requires the development of advanced medical ... -
Three-Dimensional Laminin Mimetic Peptide Nanofiber Gels for In Vitro Neural Differentiation
(Wiley-VCH Verlag, 2017)The extracellular matrix (ECM) provides biochemical signals and structural support for cells, and its functional imitation is a fundamental aspect of biomaterial design for regenerative medicine applications. The stimulation ... -
Toxicity of internalized laser generated pure silver nanoparticles to the isolated rat hippocampus cells
(SAGE, 2017-02)Silver nanoparticles (AgNPs) are the most commonly used nanoparticles (NPs) in medicine, industry and cosmetics. They are generally considered as biocompatible. However, contradictory reports on their biosafety render them ...
