Browsing by Keywords "Exosomes"
Now showing items 1-8 of 8
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The development of prophylactic and therapeutic vaccine using cell derived extracellular vesicles
(Bilkent University, 2022-08)The primary aim of this thesis is to extend the breadth of in vivo application of externally loaded cell-line derived and tumor derived exosomes as a prophylactic and therapeutic carrier against cancer treatment. Exosomes ... -
Efficient production and enhanced tumor delivery of engineered extracellular vesicles
(Elsevier Ltd, 2016)Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized intercellular communication vehicles that participate in a multitude of physiological processes. Due to their biological properties, they ... -
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
(American Chemical Society, 2016-03)Recent research has demonstrated that all body fluids assessed contain substantial amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes containing different membrane ... -
Immunomodulatory effects of exosomes: promising candidates in immunotherapy
(Bilkent University, 2018-08)Exosomes are type of extracellular vesicles secreted from almost all cell types and carry numerous biological molecules such as nucleic acids, protein and lipids. They mediate many cellular processes including cellular ... -
Immunomodulatory potential of human umbilical cord tissue-derived mesenchymal stromal cell (UCX®) exosomes in combination with immunosuppressive “A151” oligodeoxynucleotide
(Bilkent University, 2019-07)Mesenchymal stromal or stem cells (MSCs) modulate immune responses apart from their regenerative capacities. Accumulating evidence suggests that MSCs exert their paracrine effects through extracellular vesicles known as ... -
Immunotherapeutic action of extracellular vesicles and effects of TLR signaling to immune dysfunction of SCI patients
(Bilkent University, 2017-03)The primary aim of this thesis is to extend the breadth of in vivo application of externally loaded exosomes as prophylactic or therapeutic carriers against disease treatment. Exosomes are secreted from all cells and ... -
Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infection
(Scientific and Technical Research Council of Turkey, 2020)Discovery of novel and broad-acting immunomodulators is of critical importance for the prevention and treatment of disorders occurring due to overexuberant immune responseincluding SARS-CoV-2 triggered cytokine storm leading ... -
Therapeutic and diagnostic applications of extracellular vesicles
(Bilkent University, 2016-03)Extracellular vesicles (EV), consisting of exosomes and microvesicles, are secreted biological nanovesicles and assumed plethora of physiological functions ranging from transport of cargo, regulating distant cell communication, ...
