Browsing by Keywords "Endophenotypes"

Now showing items 1-2 of 2

Heritability of neuropsychological measures in schizophrenia and nonpsychiatric populations: a systematic review and meta-analysis

Blokland, G. A. M.; Mesholam-Gately, R. I.; Toulopoulou, T.; Del Re, E. C.; Lam, M.; Delisi, L. E.; Donohoe, G.; Walters, J. T. R.; Seidman, L. J.; Petryshen, T. L. (Oxford University Press, 2017)

Schizophrenia is characterized by neuropsychological deficits across many cognitive domains. Cognitive phenotypes with high heritability and genetic overlap with schizophrenia liability can help elucidate the mechanisms ...
Polygenic risk score increases schizophrenia liability through cognition-relevant pathways

Toulopoulou, Timothea; Zhang, X.; Cherny, S.; Dickinson, D.; Berman, K. F.; Straub, R. E.; Sham, P.; Weinberger, D. R. (Oxford University Press, 2019)

Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct causality from the former to the ...