Browsing by Keywords "ER stress"
Now showing items 1-7 of 7
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The effects of ER stress on glial cells: evidence from both in vivo and in vitro models
(Bilkent University, 2022-01)Consuming high fat diet for long periods of time increases neuroinflammation, which may result in cognitive decline and loss in memory formation. Excessive free fatty acid influx stresses the ER and mitochondria, two ... -
Enhanced expression of HNF4α during intestinal epithelial differentiation is involved in the activation of ER stress
(Wiley, 2020)Intestinal epithelial cells are derived from stem cells at the crypts that undergo differentiation into transit‐amplifying cells, which in turn form terminally differentiated enterocytes as these cells reach the villus. ... -
Identification of a novel substrate of IRE1 in lipotoxic stress response
(Bilkent University, 2022-02)Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is a ribonucleic acid (RNA)-binding protein (RBP) that controls translation of select messenger RNAs (mRNAs). ... -
Inositol‐requiring enzyme‐1 regulates phosphoinositide signaling lipids and macrophage growth
(Wiley-VCH Verlag, 2020-11)The ER‐bound kinase/endoribonuclease (RNase), inositol‐requiring enzyme‐1 (IRE1), regulates the phylogenetically most conserved arm of the unfolded protein response (UPR). However, the complex biology and pathology regulated ... -
Lipotoxic endoplasmic reticulum stress-associated inflammation : molecular mechanisms and modification by a bioactive lipokine
(Bilkent University, 2012)Physiologic or pathologic processes that disturb protein folding in the endoplasmic reticulum (ER) activate a signaling pathway named the unfolded protein response (UPR). UPR promotes cell survival by reducing misfolded ... -
The role of lipid-induced integrated stress response in metaflammation and atherosclerosis
(Bilkent University, 2019-07)Chronic inflammation resulting from metabolic overloading of organelles (such as the endoplasmic reticulum (ER) and mitochondria that control cellular homeostasis) is a major cause of metabolic disorders including diabetes, ... -
The role of Protein Kinase R in lipotoxicity
(Bilkent University, 2013)Endoplasmic reticulum (ER) is a central organelle for cellular homeostasis through its myriad of functions including protein and lipid biosynthesis, protein folding and secretion and calcium homeostasis. When protein ...
