Browsing by Keywords "DNA damage"
Now showing items 1-4 of 4
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Cancer testis gene expression as a biomarker of one-carbon metabolic activity, drug sensitivity and phenotypic heterogeneity in non-small cell lung cancer and malignant melanoma
(Bilkent University, 2016-09)Expression of cancer-testis (CT) genes on X chromosome (CT-X) is restricted to tumors, with very low or no expression in normal adult tissues. CT-X gene expression is one of the factors contributing to tumor heterogeneity ... -
Differential p21 expression after ionizing and UVC radiation in EBV-transformed lymphoblastoid cells
(2000)Responses to DNA-damaging agents appear to be coordinated by p53 through transcriptional activation of critical target genes. Among them, p21WAF1 encodes a protein preventing cells from entering S phase. It is not clear ... -
p53 mutations as fingerprints of environmental carcinogens
(2000)Mutations of the p53 tumor suppressor gene occur in a great majority of human cancers. The protein product of p53 gene is involved in DNA damage response. Consequently, p53 gene may be a preferred target for environmental ... -
PATZ1 is a DNA damage-responsive transcription factor that inhibits p53 function
(American Society for Microbiology, 2015)Insults to cellular health cause p53 protein accumulation, and loss of p53 function leads to tumorigenesis. Thus, p53 has to be tightly controlled. Here we report that the BTB/POZ domain transcription factor PATZ1 (MAZR), ...
