Browsing by Keywords "Colorectal cancer"

Now showing items 1-8 of 8

15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1

Tunçer, S.; Keşküş, A. G.; Çolakoğlu, M.; Çimen, I.; Yener, C.; Konu, Ö.; Banerjee, S. (Elsevier, 2017-11)

15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been ...
Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT–PNA molecular beacons

Kam, Y.; Rubinstein, A.; Naik, S.; Djavsarov, I.; Halle, D.; Ariel, I.; Gure, A. O.; Stojadinovic, A.; Pan, H. G.; Tsivin, V.; Nissan, A.; Yavin, E. (Elsevier Ireland Ltd., 2014-09-28)

Although the function and mechanism of action of long non-coding RNAs (lncRNA) is still not completely known, studies have shown their potential role in the control of gene expression and regulation, in cellular proliferation ...
Early detection and staging of colorectal cancer using a panel of micro RNAs

Shapira, R.; Ilyayev, N.; Attali, R.; Westrich, G.; Halle, D.; Speter, C.; Stavropoulos, A. V.; Roistacher, M.; Pavlov, V.; Grinbaum, R.; Protic, P.; Gure, A. O.; Bilchik, A. J.; Stojadinovic, A.; Mitrani-Rosenbaum, S.; Nissan, A. (OMICS, 2018)

Purpose: To improve lymph node (LN) staging in patients with colon cancer (CC). The present study describes the selection of CC-specific miRNAs and assesses their utility as a micro metastases detection assay. Methods: ...
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

Gao J.; Aksoy, B. A.; Dogrusoz, U.; Dresdner, G.; Gross, B.; Sumer, S. O.; Sun, Y.; Jacobsen, A.; Sinha, R.; Larsson, E.; Cerami, E.; Sander, C.; Schultz, N. (American Association for the Advancement of Science (A A A S), 2013)

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer ...
Interplay between 15-lipoxygenase-1 and metastasisassociated antigen 1 in the metastatic potential of colorectal cancer

Tunçer, S.; Çağatay, T. S.; Keşküş, A. G.; Çolakoğlu, M.; Konu, Ö.; Banerjee S. (Wiley-Blackwell Publishing Ltd., 2016)

Objectives: Metastasis-associated antigen 1 (MTA1) is implicated in metastasis while 15-lipoxygenase-1 (15-LOX-1) reduces cell motility, when re-expressed in colorectal cancer (CRC). We aimed to understand any potential ...
Lower connectivity of tumor coexpression networks is not specific to cancer

Dalgıç, E.; Konu, Özlen; Safi Öz, Z.; Chan, C. (IOP, 2019-05)

Global level network analysis of molecular links is necessary for systems level view of complex diseases like cancer. Using genome-wide expression datasets, we constructed and compared gene co-expression based specific ...
Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer

Taskoparan, B.; Seza, E. G.; Demirkol, S.; Tuncer, S.; Stefek, M.; Gure, A. O.; Banerjee, S. (Springer Netherlands, 2017-09)

Purpose: Aldo-keto reductases (including AKR1B1 and AKR1B10) constitute a family of oxidoreductases that have been implicated in the pathophysiology of diabetes and cancer, including colorectal cancer (CRC). Available data ...
p53 mutations as fingerprints of environmental carcinogens

Cetin-Atalay, R.; Ozturk, M. (2000)

Mutations of the p53 tumor suppressor gene occur in a great majority of human cancers. The protein product of p53 gene is involved in DNA damage response. Consequently, p53 gene may be a preferred target for environmental ...