Now showing items 1-9 of 9

    • Contact guidance enhances the quality of a tissue engineered corneal stroma 

      Vrana, E.; Builles, N.; Hindie, M.; Damour O.; Aydinli, A.; Hasirci, V. (John Wiley & Sons, Inc., 2008)
      Corneal stroma is a very complex structure, composed of 200 lamellae of oriented collagen fibers. This highly complex nature of cornea is known to be important for its transparency and mechanical integrity. Thus, an ...
    • Cornea engineering on polyester carriers 

      Zorlutuna, P.; Tezcaner, A.; Kiyat, I.; Aydinli, A.; Hasirci, V. (John Wiley & Sons, Inc., 2006)
      In this study, biodegradable polyester based carriers were designed for tissue engineering of the epithelial and the stromal layers of the cornea, and the final construct was tested in vitro. In the construction of the ...
    • Development of bioactive peptide nanofibers for intervertebral disc regeneration 

      Uysal, Özge (Bilkent University, 2017-08)
      Lower back pain (LBP) and neck problems are the most common orthopedic diseases worldwide, and the main reason behind LBP is intervertebral disc degeneration (IVDD). Therefore, specialized therapeutic applications to induce ...
    • Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice 

      Senturk, B.; Demircan, B. M.; Ozkan A.D.; Tohumeken, S.; Delibasi, T.; Guler, M. O.; Tekinay, A. B. (Royal Society of Chemistry, 2017)
      There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist ...
    • Effect of double growth factor release on cartilage tissue engineering 

      Ertan, A.B.; Yilgor P.; Bayyurt, B.; Çalikoǧlu, A.C.; Kaspar Ç.; Kök F.N.; Kose G.T.; Hasirci V. (2013)
      The effects of double release of insulin-like growth factor I (IGF-I) and growth factor β1 (TGF-β1) from nanoparticles on the growth of bone marrow mesenchymal stem cells and their differentiation into cartilage cells were ...
    • Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury 

      Yergoz, F.; Hastar, N.; Cimenci, C. E.; Ozkan, A. D.; Guler, M. O.; Tekinay, A. B.; Tekinay, T.; Guler, M. O. (Elsevier Ltd, 2017)
      Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, ...
    • A hybrid nanofiber matrix to control the survival and maturation of brain neurons 

      Sur, S.; Pashuck, E. T.; Guler, M. O.; Ito, M.; Stupp, S. I.; Launey, T. (Elsevier BV, 2012)
      Scaffold design plays a crucial role in developing graft-based regenerative strategies, especially when intended to be used in a highly ordered nerve tissue. Here we describe a hybrid matrix approach, which combines the ...
    • A new tool for differentiating hepatocellular cancer cells: patterned carbon nanotube arrays 

      Kucukayan-Dogu, G.; Gozen, D.; Bitirim, V.; Akcali, K. C.; Bengu, E. (Elsevier, 2015)
      We aimed to develop a new approach to detect the invasiveness and metastatic degree of hepatocellular carcinoma cells (HCC) based on their epithelial mesenchymal transition (EMT) status by using patterned carbon nanotubes ...
    • Patterned carbon nanotubes as a new three-dimensional scaffold for mesenchymal stem cells 

      Bitirim V.C.; Kucukayan-Dogu G.; Bengu, E.; Akcali, K.C. (2013)
      We investigated the cellular adhesive features of mesenchymal stem cells (MSC) on non-coated and collagen coated patterned and vertically aligned carbon nanotube (CNT) structures mimicking the natural extra cellular matrix ...