Browsing by Keywords "Cell Proliferation"

Application of the Ugi reaction with multiple amino acid-derived components: Synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics

Stucchi, M.; Cairati, S.; Cetin-Atalay, R.; Christodoulou, M.S.; Grazioso G.; Pescitelli G.; Silvani, A.; Yildirim, D.C.; Lesma G. (Royal Society of Chemistry, 2015)

The concurrent employment of α-amino acid-derived chiral components such as aldehydes and α-isocyanoacetates, in a sequential Ugi reaction/cyclization two-step strategy, opens the door to the synthesis of three structurally ...

Effect of double growth factor release on cartilage tissue engineering

Ertan, A.B.; Yilgor P.; Bayyurt, B.; Çalikoǧlu, A.C.; Kaspar Ç.; Kök F.N.; Kose G.T.; Hasirci V. (2013)

The effects of double release of insulin-like growth factor I (IGF-I) and growth factor β1 (TGF-β1) from nanoparticles on the growth of bone marrow mesenchymal stem cells and their differentiation into cartilage cells were ...

Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy

Spisek, R.; Kukreja, A.; Chen, L. -C.; Matthews, P.; Mazumder, A.; Vesole, D.; Jagannath, S.; Zebroski, H. A.; Simpson, A. J. G.; Ritter, G.; Durie, B.; Crowley, J.; Shaughnessy, Jr. J.D.; Scanlan, M. J.; Gure, A. O.; Barlogie, B.; Dhodapkar, M. V. (Rockefeller University Press, 2007)

Specific targets of cellular immunity in human premalignancy are largely unknown. Monoclonal gammopathy of undetermined significance (MGUS) represents a precursor lesion to myeloma (MM). We show that antigenic targets of ...

HER2 and proliferation of wound-induced breast carcinoma

Tez, M.; Göçmen, E.; Özçelik, T. (The Lancet Publishing, 2003-11-01)

Identification of novel neutralizing single-chain antibodies against vascular endothelial growth factor receptor 2

Erdag, B.; Koray Balcioglu, B.; Ozdemir Bahadir, A.; Serhatli, M.; Kacar O.; Bahar, A.; Seker, U.O.S.; Akgun, E.; Ozkan, A.; Kilic, T.; Tamerler, C.; Baysal, K. (2011)

Human vascular endothelial growth factor (VEGF) and its receptor (VEGFR-2/kinase domain receptor [KDR]) play a crucial role in angiogenesis, which makes the VEGFR-2 signaling pathway a major target for therapeutic applications. ...

Spatial organization of functional groups on bioactive supramolecular glycopeptide nanofibers for differentiation of mesenchymal stem cells (MSCs) to brown adipogenesis

Caliskan, O. S.; Sardan, Ekiz M.; Tekinay, A. B.; Güler, Mustafa O. (American Chemical Society, 2016-12)

Spatial organization of bioactive moieties in biological materials has significant impact on the function and efficiency of these systems. Here, we demonstrate the effect of spatial organization of functional groups including ...

Synthesis and anticancer activity evaluation of some benzothiazole-piperazine derivatives

Gurdal, E.E.; Buclulgan, E.; Durmaz I.; Cetin-Atalay, R.; Yarim, M. (Bentham Science Publishers B.V., 2015)

Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and ...

Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

Demir, Z.; Guven, E.B.; Ozbey, S.; Kazak, C.; Atalay, R.C.; Tuncbilek, M. (Elsevier Masson SAS, 2015)

Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was ...

Texturing of titanium (Ti6Al4V) medical implant surfaces with MHz-repetition-rate femtosecond and picosecond Yb-doped fiber lasers

Erdoǧan, M.; Öktem, B.; Kalaycioǧlu H.; Yavaş, S.; Mukhopadhyay P.K.; Eken, K.; Özgören, K.; Aykaç, Y.; Tazebay, U.H.; Ilday F.O. (Optical Society of American (OSA), 2011)

We propose and demonstrate the use of short pulsed fiber lasers in surface texturing using MHz-repetition-rate, microjoule- and sub-microjoule-energy pulses. Texturing of titanium-based (Ti6Al4V) dental implant surfaces ...