Now showing items 1-2 of 2

    • Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers 

      Siddiqui, A.; Gollavilli, P. N.; Schwab, A.; Vazakidou, M. E.; Ersan, Pelin G.; Ramakrishnan, M.; Pluim, D.; Coggins, Si’A.; Saatçi, Ö.; Annaratone, L.; Schellens, J. HM; Kim, B.; Asangani, İ. A.; Rasheed, S. A. K.; Marchiò, C.; Şahin, Özgür; Ceppi, P. (Nature Publishing Group, 2019-02)
      Cancer cells frequently boost nucleotide metabolism (NM) to support their increased proliferation, but the consequences of elevated NM on tumor de-differentiation are mostly unexplored. Here, we identified a role for ...
    • Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression 

      Chang, C.; Zhang, C.; Zhang, Q.; Sahin, O.; Wang, H.; Xu, J.; Xiao, Y.; Zhang, J.; Rehman, S. K.; Li, P.; Hung, M. C.; Behbod, F.; Yu, D. (Impact Journals LLC, 2016-05)
      Metabolic reprogramming is a hallmark of cancer. Elevated glycolysis in cancer cells switches the cellular metabolic flux to produce more biological building blocks, thereby sustaining rapid proliferation. Recently, new ...