Browsing by Keywords "CHRNA5"
Now showing items 1-11 of 11
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Analysis of CHRNA5 expression in breast cancer cell lines in response to serum starvation and estrogen treatment
(Bilkent University, 2013)Breast cancer is a complex disease that can be classified into distinct molecular subtypes including Basal, Luminal A, Luminal B and HER2 positive. These molecular subtypes mainly differ in their hormone receptor ... -
CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer
(Springer, 2021-04)Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of ... -
Development of a WEB application
(Bilkent University, 2011)microRNAs, small non-coding RNA molecules with important roles in cellular machinery, target mRNAs for silencing by binding generally to their 3’ UTR sequences via partial base complementation. Thus, microRNAs with ... -
Development of novel tools for cancer diagnosis, prognosis and treatment using intra- or inter-species transcriptome metaanalysis
(Bilkent University, 2017-08)In the past decades, a considerable number of studies have performed meta-analysis on large data collections to prioritize sets of genes, pathways or types/categories of disease focusing on either differential expression, ... -
Effects of Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi on apoptosis, DNA damage response, drug sensitivity, and HSA-MIR-495-3P overexpression in breast cancer
(Bilkent University, 2018-12)Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is associated with nicotine addiction and it has an important role in the prognosis of lung cancer. Despite its important cellular functions, its role in breast cancer remains ... -
Effects of depletion of CHRNA5 and/or TP53, and transient and stable overexpression of wildtype or mutant TP53 on expression of DLK1-MEG3 locus in MCF7 cells
(Bilkent University, 2022-09)The expression of CHRNA5 has a prominent role in lung cancer and nicotine addiction. Besides, depletion of CHRNA5 has been identified as being tumour suppressive in breast cancer. Moreover, CHRNA5 depletion causes increases ... -
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has been initially shown in the lung tissue in ... -
hsa-miR-497 as a modulator of the expression in the presence or absence of chrna5 in breast cancer
(Bilkent University, 2017-06)CHRNA5 is an important ligand-gated receptor with roles in addiction and in cancer. In lung cancer, CHRNA5 dysregulation is well known. There is also expression of CHRNA5 in breast cancer cell lines. microRNAs regulate ... -
Identification of modulatory functions of TP53, estrogen signaling, and 14q32.31 miRNA cluster on CHRNA5 knock-down expression profile and development of syneRgy APP
(Bilkent University, 2021-09)Cholinergic receptor subunit alpha 5 (CHRNA5) is a ligand-gated ion channel expressed in not only the nervous system but also other tissues. Differential expression and the polymorphisms of CHRNA5 have been associated with ... -
Investigation of novel RNAi and nanoparticle approaches for their anti-proliferative and drug-sensitizing effects in breast cancer
(Bilkent University, 2017-08)Drug resistivity remains a major challenge in treating different cancer types. Among several strategies adapted to increase drug sensitivity in breast cancer cells, in the present thesis I studied an RNAi molecule targeting ... -
qPCR validation of in vivo diagnostic importance and regulation by estrogen for CHRNA5 isoform expression in breast cancer
(Bilkent University, 2014)Breast cancer has multiple molecular subtypes; normal-like, basal-like, luminal A, luminal B and HER2 positive depending on receptor status of tumor cells. Cancer therapy is tailored according to the type of cancer; hence ...
