Browsing by Keywords "Breast cancer"
Now showing items 1-20 of 53
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Analysis of CHRNA5 expression in breast cancer cell lines in response to serum starvation and estrogen treatment
(Bilkent University, 2013)Breast cancer is a complex disease that can be classified into distinct molecular subtypes including Basal, Luminal A, Luminal B and HER2 positive. These molecular subtypes mainly differ in their hormone receptor ... -
Analysis of the ATAD2 gene effect on the genes involved in epithelial mesenchymal transition in estrogen positive and negative breast cancers
(Bilkent University, 2021-02)ATAD2 is overexpressed in many distinct cancer types including breast cancer. Its elevated expression is an indicator of poor prognosis. High ATAD2 expression correlates with short overall survival, disease-free survival ... -
Analysis of the effect of Erbin on the epithelial to mesenchymal transition related genes in breast cancer
(Bilkent University, 2022-09)Breast cancer is a heterogeneous disease and has complex mechanisms, which brings the need to come up with different approaches for its various types. Erbin is a member of the LAP family and directly interacts with ErbB2 ... -
BO-264: Highly potent TACC3 inhibitor as a novel anticancer drug candidate
(Bilkent University, 2021-01)Breast cancer has been consistently ranked to be the most common cancer and the second leading cause of cancer-related death in women worldwide for many years. Despite better understanding of tumor biology and the availability ... -
Characterization of chemosensitivity profiles of breast cancer cell lınes, with and without stem cell like features = Kök-hücre özelliği olan ve olmayan meme kanseri hücre hatlarının ilaç hassasiyet profillerinin tanımlanması
(Bilkent University, 2014)Breast cancer is the second most common cause of death worldwide from cancer due to complications with its diagnosis and resistance to therapy. Recent studies have shown that breast tumors when compared with other solid ... -
CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer
(Springer, 2021-04)Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of ... -
Combinatorial targeting of PI3K and MAPK pathways by miR-564 to inhibit proliferation and invasion in breast cancer
(Bilkent University, 2016-07)Breast cancer is among most common malignant tumors worldwide and one of the deadliest cancer types among women. Like other cancer types, dysregulation of signaling pathways is the major cause of uncontrolled cell ... -
A comprehensive methodology for determining the most informative mammographic features
(2013)This study aims to determine the most informative mammographic features for breast cancer diagnosis using mutual information (MI) analysis. Our Health Insurance Portability and Accountability Act-approved database consists ... -
Concomitant inactivation of p53 and Chk2 in breast cancer
(Nature Publishing Group, 2002) -
Cytotoxic activity of resveratrol in different cell lines evaluated by MTT and NRU assays
(Turkish Pharmacists Association, 2016)Oxidative stress is the state of imbalance between the level of antioxidant defence system and production of reactive oxygen species (ROS) and is involded in the progression of several diseases such as inflammation, cancer, ... -
Detection of microcalcifications in mammograms using local maxima and adaptive wavelet transform analysis
(The Institution of Engineering and Technology(IET), 2002-10-24)A method for computer-aided diagnosis of microcalcification clusters in mammogram images is presented. Microcalcification clusters which are an early sign of breast cancer appear as isolated bright spots in mammograms. ... -
Development of a shiny application for comparative transcriptomics and differential gene expression analysis
(Bilkent University, 2022-09)RNA sequencing has proven to be an effective technique for divulging information about the transcriptome in molecular biology research. Compared to microarrays and early methods of cDNA sequencing, high-throughput RNA ... -
Development of novel tools for cancer diagnosis, prognosis and treatment using intra- or inter-species transcriptome metaanalysis
(Bilkent University, 2017-08)In the past decades, a considerable number of studies have performed meta-analysis on large data collections to prioritize sets of genes, pathways or types/categories of disease focusing on either differential expression, ... -
Effects of depletion of CHRNA5 and/or TP53, and transient and stable overexpression of wildtype or mutant TP53 on expression of DLK1-MEG3 locus in MCF7 cells
(Bilkent University, 2022-09)The expression of CHRNA5 has a prominent role in lung cancer and nicotine addiction. Besides, depletion of CHRNA5 has been identified as being tumour suppressive in breast cancer. Moreover, CHRNA5 depletion causes increases ... -
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has been initially shown in the lung tissue in ... -
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers
(Nature Publishing Group, 2021-10-30)Epidermal growth factor receptor (EGFR) has critical roles in epithelial cell physiology. Over-expression and over-activation of EGFR have been implicated in diverse cancers, including triple-negative breast cancers (TNBCs), ... -
The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographicaly diverse populations
(Cell Press, 2000)Recently, a 6-kb duplication of exon 13, which creates a frameshift in the coding sequence of the BRCA1 gene, has been described in three unrelated U.S. families of European ancestry and in one Portuguese family. Here, our ... -
Functional analysis of Erbin gene in breast cancer drug resistance
(Bilkent University, 2021-02)Erbin is an ERBB2 interacting protein with roles in many signaling pathways. Breast cancer is one of the types of cancer that is affected by Erbin regulation. However, it is unclear how Erbin regulates the biological ... -
Functional effects of ATAD2 gene expression in breast cancer
(Bilkent University, 2016-08)The ATAD2 gene is a newly investigated gene of which the expression levels are associated with the disease prognosis in many types of cancer and especially breast cancer and that is known to be overexpressed usually through ... -
Functional genomics in translational cancer research: focus on breast cancer
(Oxford University Press, 2008)Conventional molecular and genetic methods for studying cancer are limited to the analysis of one locus at a time. A cluster of genes that are regulated together can be identified by DNA microarray, and the functional ...
