Browsing by Keywords "Breast Cancer"
Now showing items 1-10 of 10
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Analysis of 45S rDNA promoter methylation and expression of rRNA transcripts in breast cancer
(Bilkent University, 2015-06)Ribosome biogenesis has a central role in cell growth and proliferation that is usually disrupted in tumor cells by the inactivation of tumor suppressor genes and activation of oncogenes. Ribosomal RNA (rRNA) gene expression ... -
A comprehensive methodology for determining the most informative mammographic features
(2013)This study aims to determine the most informative mammographic features for breast cancer diagnosis using mutual information (MI) analysis. Our Health Insurance Portability and Accountability Act-approved database consists ... -
Effects of biological compound Turkish propolis extract on breast cancer cells
(Bilkent University, 2013)Propolis is a resinous compound which is collected from various plants then combined with wax and bee enzymes by worker bees. There are many studies conducted on propolis or its active components aiming to find new ... -
Effects of Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi on apoptosis, DNA damage response, drug sensitivity, and HSA-MIR-495-3P overexpression in breast cancer
(Bilkent University, 2018-12)Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is associated with nicotine addiction and it has an important role in the prognosis of lung cancer. Despite its important cellular functions, its role in breast cancer remains ... -
Evaluation of TAGLN as a diagnostic marker in breast cancer
(Bilkent University, 2018-09)Silecing of tumor suppressor genes via CpG hypermethylation in promoter regions is one of the frequent events occurring in different types of cancers. These genes have the potential as a diagnostic or a prognostic ... -
Functional analysis of transgelin in breast cancer
(Bilkent University, 2018-06)Transgelin (TAGLN) is an actin-binding protein. It is highly expressed in fibroblasts and smooth muscle cells. In smooth muscle cells, it takes part in processes including motility and differentiation and also it has a ... -
Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α
(BioMed Central, 2012)Background: One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular domain ... -
qPCR validation of in vivo diagnostic importance and regulation by estrogen for CHRNA5 isoform expression in breast cancer
(Bilkent University, 2014)Breast cancer has multiple molecular subtypes; normal-like, basal-like, luminal A, luminal B and HER2 positive depending on receptor status of tumor cells. Cancer therapy is tailored according to the type of cancer; hence ... -
A simulation optimization for breast cancer screening in Turkey
(Bilkent University, 2014)Breast cancer is the most common cancer type among women in the world. 6.3 million women were diagnosed with breast cancer between 2007 - 2012 and 25% of cancers in women are breast cancer. Early diagnosis and early ... -
Unliganded estrogen receptor-x activates transcription of the mammary gland Na+/I-symporter gene
(Elsevier, 2006)The function of sodium iodide symporter (Na+/I symporter, or NIS) in mammary epithelial cells is essential for the accumulation of I in milk; the newborn’s first source of I for thyroid hormone synthesis. Furthermore, ...
