Now showing items 1-4 of 4

    • Germline mutations in the BRCA1 and BRCA2 genes in Turkish breast ovarian cancer patients 

      Manguoglu, A. E.; Lüleci, G.; Özçelik, T.; Çolak, T.; Schayek, H.; Akaydin, M.; Friedman, E. (John Wiley & Sons, Inc., 2003)
      In this study we genotyped Turkish breast/ovarian cancer patients for BRCA1/BRCA2 mutations: protein truncation test (PTT) for exon 11 BRCA1 of and, multiplex PCR and denaturing gradient gel electrophoresis (DGGE) for ...
    • Identification of genes induced by BRCA1 in breast cancer cells 

      Atalay, A.; Crook, T.; Ozturk, M.; Yulug, I. G. (Academic press, 2002)
      Inherited mutations of the BRCA1 gene predispose to breast, ovarian, and other cancers. The role of the BRCA1 gene in the maintenance of chromosomal integrity is linked to a number of biological properties of its protein ...
    • p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1-and BRCA2-associated breast tumours 

      Crook, T.; Brooks, L. A.; Crossland, S.; Osin, P.; Barker, K. T.; Waller, J.; Philp, E.; Smith, P. D.; Yulug, I.; Peto, J.; Parker, G.; Allday, M. J.; Crompton, M. R.; Gusterson, B. A. (Nature Publishing Group, 1998)
      The status of p53 was investigated in breast tumours arising in germ-line carriers of mutant alleles of BRCA1 and BRCA2 and in a control series of sporadic breast tumours. p53 expression was detected in 20/26 (77%) BRCA1-, ...
    • TP53 mutations in familial breast cancer: Functional aspects 

      Gasco, M.; Yulug, I. G.; Crook, T. (John Wiley & Sons, Inc., 2003)
      Mutation in p53 (TP53) remains one of the most commonly described genetic events in human neoplasia. The occurrence of mutations is somewhat less common in sporadic breast carcinomas than in other cancers, with an overall ...