Now showing items 1-20 of 144

    • 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1 

      Tunçer, S.; Keşküş, A. G.; Çolakoğlu, M.; Çimen, I.; Yener, C.; Konu, Ö.; Banerjee, S. (Elsevier, 2017-11)
      15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been ...
    • 3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines 

      Önen-Bayram F.E.; Buran, K.; Durmaz I.; Berk, B.; Cetin-Atalay, R. (Royal Society of Chemistry, 2015)
      Cancer results from unregulated cell growth. Reactivating the process of the programmed cell death, i.e. apoptosis, is a classical anticancer therapeutic strategy. The apoptosis-inducing property of the (2RS,4R)-2-phenyl ...
    • Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells 

      Küçük, C.; Jiang, B.; Hu X.; Zhang W.; Chan J.K.C.; Xiao W.; Lack, N.; Alkan, C.; Williams J.C.; Avery, K.N.; Kavak P.; Scuto, A.; Sen, E.; Gaulard P.; Staudt L.; Iqbal J.; Zhang W.; Cornish, A.; Gong Q.; Yang Q.; Sun H.; D'Amore F.; Leppä, S.; Liu W.; Fu, K.; De Leval L.; McKeithan, T.; Chan W.C. (Nature Publishing Group, 2015)
      Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell ...
    • Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment 

      Cekic, C.; Linden J. (American Association for Cancer Research Inc., 2014)
      Adenosine A2A receptor (A2AR) blockade enhances innate and adaptive immune responses. However, mouse genetic studies have shown that A2AR deletion does not inhibit the growth of all tumor types. In the current study, we ...
    • Alkaline phosphatase-mimicking peptide nanofibers for osteogenic differentiation 

      Gulseren, G.; Yasa, I. C.; Ustahuseyin, O.; Tekin, E. D.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2015)
      Recognition of molecules and regulation of extracellular matrix synthesis are some of the functions of enzymes in addition to their catalytic activity. While a diverse array of enzyme-like materials have been developed, ...
    • Almost quantum correlations 

      Navascués, M.; Guryanova, Y.; Hoban, M.J.; Acín, A. (Nature Publishing Group, 2015)
      Quantum theory is not only successfully tested in laboratories every day but also constitutes a robust theoretical framework: small variations usually lead to implausible consequences, such as faster-than-light communication. ...
    • Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias 

      Akyerli, C. B.; Özbek, U.; Aydin-Sayitoǧlu, M.; Sirma, S.; Özçelik, T. (Springer, 2003)
      [No abstract available]
    • Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds 

      Uzunalli, G.; Mammadov R.; Yesildal, F.; Alhan, D.; Ozturk, S.; Ozgurtas, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2017)
      Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of ...
    • Angiogenic peptide nanofibers improve wound healing in STZ-induced diabetic rats 

      Senturk, B.; Mercan, S.; Delibasi, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2016-06)
      Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity ...
    • Angiogenic peptide nanofibers repair cardiac tissue defect after myocardial infarction 

      Rufaihah, A. J.; Yasa, I. C.; Ramanujam, V. S.; Arularasu, S. C.; Kofidis, T.; Guler, M. O.; Tekinay, A. B. (Acta Materialia Inc, 2017)
      Myocardial infarction remains one of the top leading causes of death in the world and the damage sustained in the heart eventually develops into heart failure. Limited conventional treatment options due to the inability ...
    • Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles 

      Çikla-Süzgün P.; Kaushik-Basu, N.; Basu, A.; Arora P.; Talele, T.T.; Durmaz I.; Çetin-Atalay, R.; Küçükgüzel, S.G. (Taylor and Francis Ltd, 2015)
      Arachidonic acid is an unsaturated fatty acid liberated from phospholipids of cell membranes. NSAIDs are known as targets of cyclooxygenase enzyme (COX-1, COX-2 and COX-3) in arachidonic acid metabolism. This mechanism of ...
    • Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes 

      Celebioglu A.; Umu, O. C. O.; Tekinay, T.; Uyar T. (Elsevier, 2014)
      The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were ...
    • Antibacterial electrospun zein nanofibrous web encapsulating thymol/cyclodextrin-inclusion complex for food packaging 

      Aytac Z.; Ipek, S.; Durgun, E.; Tekinay, T.; Uyar T. (Elsevier, 2017-10)
      Thymol (THY)/γ-Cyclodextrin(γ-CD) inclusion complex (IC) encapsulated electrospun zein nanofibrous webs (zein-THY/γ-CD-IC-NF) were fabricated as a food packaging material. The formation of THY/γ-CD-IC (1:1 and 2:1) was ...
    • Approximate fourier domain expression for bloch-siegert shift 

      Turk, E. A.; Ider, Y. Z.; Ergun, A. S.; Atalar, E. (John Wiley and Sons Inc., 2015)
      Purpose: In this study, a newsimple Fourier domain-based analytical expression for the Bloch-Siegert (BS) shift-based B1 mapping method is proposed to obtain |B1+| more accurately while using short BS pulse durations and ...
    • Atomic scale study of superlow friction between hydrogenated diamond surfaces 

      Dag, S.; Ciraci, S. (American Physical Society, 2004)
      Strong attractive interaction between two clean diamond (001) slabs turns repulsive upon the hydrogenation of surfaces. This repulsive interaction serves as if a boundary lubricant and prevents the sliding surfaces from ...
    • Audiovisual associations alter the perception of low-level visual motion 

      Kafaligonul H.; Oluk, C. (Frontiers Research Foundation, 2015)
      Motion perception is a pervasive nature of vision and is affected by both immediate pattern of sensory inputs and prior experiences acquired through associations. Recently, several studies reported that an association can ...
    • Bacteria encapsulated electrospun nanofibrous webs for remediation of methylene blue dye in water 

      Sarioglu O.F.; Keskin, N. O. S.; Celebioglu A.; Tekinay, T.; Uyar T. (Elsevier, 2017-04)
      In this study, preparation and application of novel biocomposite materials that were produced by encapsulation of bacterial cells within electrospun nanofibrous webs are described. A commercial strain of Pseudomonas ...
    • Biocompatibility studies on lanthanum oxide nanoparticles 

      Brabu, B.; Haribabu, S.; Revathy, M.; Anitha, S.; Thangapandiyan, M.; Navaneethakrishnan, K. R.; Gopalakrishnan, C.; Murugan, S. S.; Kumaravel, T. S. (Royal Society of Chemistry, 2015)
      Lanthanum oxide nanoparticles (LONP), a rare earth metal oxide, have unique properties that make them a suitable candidate for several biomedical applications. We investigated certain key in vitro and in vivo biocompatibility ...
    • Biocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cells 

      Khalily, M. A.; Gulseren, G.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2015)
      Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal ...
    • Biosystems engineering of prokaryotes with tumor-killing capacities 

      Kalyoncu, E.; Olmez, T. T.; Ozkan, A. D.; Sarioglu, O. F. (Bentham Science Publishers Ltd., 2016)
      Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic ...