Browsing by Keywords "Angiogenesis"
Now showing items 1-14 of 14
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15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1
(Elsevier, 2017-11)15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been ... -
Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds
(American Chemical Society, 2017)Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of ... -
Angiogenic peptide nanofibers improve wound healing in STZ-induced diabetic rats
(American Chemical Society, 2016-06)Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity ... -
Aspartame induces angiogenesis in vitro and in vivo models
(SAGE Publications Ltd, 2015)Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study is to evaluate the effect of aspartame on ... -
Bioactive peptide nanofibers for tissue regeneration
(Bilkent University, 2016-01)Defects in the tissues or organs caused by trauma or diseases can have detrimental effects on all aspects of patients’ life quality. During the last three decades, considerable developments have been made in tissue engineering ... -
Design and application of peptide nanofibers for modulating angiogenesis
(Bilkent University, 2016-06)Angiogenesis is important in many diseases, such as diabetic wound healing, cancer and corneal neovascularization. Angiogenesis can be induced or inhibited by complex biological systems. Mimicking the complexity in natural ... -
Electrostatic effects on the self-assembly mechanism of peptide amphiphiles
(Bilkent University, 2010)Self-assembling peptide amphiphiles, synthesized through solid phase peptide synthesis – a bottom-up approach, have been used with various tissue engineering purposes. Peptide amphiphile molecules self-assemble into nanofibers, ... -
Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury
(Elsevier Ltd, 2017)Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, ... -
HER2 and proliferation of wound-induced breast carcinoma
(The Lancet Publishing, 2003-11-01) -
Identification of novel neutralizing single-chain antibodies against vascular endothelial growth factor receptor 2
(2011)Human vascular endothelial growth factor (VEGF) and its receptor (VEGFR-2/kinase domain receptor [KDR]) play a crucial role in angiogenesis, which makes the VEGFR-2 signaling pathway a major target for therapeutic applications. ... -
Improving pancreatic islet in vitro functionality and transplantation efficiency by using heparin mimetic peptide nanofiber gels
(Elsevier, 2015)Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However, viability and functionality of the islets after transplantation are limited due to loss of integrity and destruction of blood vessel ... -
Inhibition of VEGF mediated corneal neovascularization by anti-angiogenic peptide nanofibers
(Elsevier, 2016-11)Atypical angiogenesis is one of the major symptoms of severe eye diseases, including corneal neovascularization, and the complex nature of abnormal vascularization requires targeted methods with high biocompatibility. The ... -
Mechanistic pathways of malignancy in breast cancer stem cells
(Frontiers Media S.A., 2020-04-30)Breast cancer stem cells (BCSCs) are the minor population of breast cancer (BC) cells that exhibit several phenotypes such as migration, invasion, self-renewal, and chemotherapy as well as radiotherapy resistance. Recently, ... -
Three dimensional glycosaminoglycan mimetic peptide amphiphile hydrogels for regenerative medicine applications
(Bilkent University, 2015-05)Defects and impairments of tissues or organs affect millions of people, resulting in considerable losses in workforce and life quality. The treatment of major tissue injuries requires the development of advanced medical ...
