Browsing by Keywords "Aging"
Now showing items 1-18 of 18
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Age and gender alter synaptic proteins in zebrafish (Danio Rerio) models of normal and delayed aging
(Bilkent University, 2017-07)Cognitive decline occurs during normal aging in some specific domains of cognitive abilities including but not limited to episodic memory, divided attention and executive functions, however, it is not a unitary decline ... -
Age related alterations of adult neurogenesis and astrocytes in Zebrafish (Danio Rerio)
(Bilkent University, 2019-09)Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. In order to identify appropriate interventions to change the course of brain aging and age-related neurological ... -
Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio)
(Elsevier, 2017-06)The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ... -
Effects of aging and short-term dietary restriction on neurogenesis and cellular senescence in the zebrafish (Danio Reio) brain
(Bilkent University, 2016-09)Currently we know from rodent and fish studies that adult neuron generation is reduced but still continues in old animals with a dynamic change throughout aging. This process occurs mainly in hippocampal region, which is ... -
Endothelial progenitor cells display clonal restriction in multiple myeloma
(BioMed Central Ltd., 2006)Background: In multiple myeloma (MM), increased neoangiogenesis contributes to tumor growth and disease progression. Increased levels of endothelial progenitor cells (EPCs) contribute to neoangiogenesis in MM, and, ... -
Essays on macroeconomics
(Bilkent University, 2015-09)This dissertation consists of three essays on two topics in macroeconomics. The first essay focuses on the monetary policy implications in an aging society. The second and third essays revisit the famous Shimer puzzle ... -
Expression levels of TRPC1 and TRPC6 ion channels are reciprocally altered in aging rat aorta: implications for age-related vasospastic disorders
(American Aging Association, 2010)We previously showed that the expression of transient receptor potential canonical (TRPC)6 ion channel elevated when TRPC1 was knocked down in A7r5 cultured vascular smooth muscle cells. Therefore, the purpose of this study ... -
Expression of key synaptic proteins in Zebrafish (Danio Rerio) brain following caloric restriction and its mimetic and their relationship with gender
(Bilkent University, 2017-01)Aging is a progressive decline of physiological functioning and metabolic processes. Among all the organs, the brain seems to be the most vulnerable part of the body to the age-related changes because of the relatively ... -
Gene Expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic
(BioMed Central, 2014)Background: Brain aging is a multi-factorial process due to both genetic and environmental factors. The zebrafish has recently become a popular model organism for examining aging and age-related diseases because as ... -
Housing for the aging population
(Springer, 2007-04)Based on the concept of 'aging in place,' design of houses in the past years are explored. Design features in the built environment become barriers for aging people with functional limitations. Initially, houses were ... -
Investigating the mechanisms of telomere maintenance in zebrafish tissues and human brain cancer cell lines
(Bilkent University, 2019-09)Telomeres are nucleoprotein complexes formed at each end of the chromosomes to protect these ends from deterioration. In each round of cellular division, telomeric sequences shorten due to the end replication problem of ... -
Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases
(Elsevier Inc., 2016)Normal aging is accompanied by cognitive impairment with subtle cellular and molecular changes in the brain, whereas, pathological brain aging manifests as severe behavioral impairments with cellular pathology. Understanding ... -
Novel object recognition is not affected by age despite age-related brain changes
(Scientific Research Publishing, 2013)Age-related memory impairments show a progressive decline across lifespan. Studies have demonstrated equivocal results in biological and behavioral outcomes of aging. Thus, in the present study we examined the novel object ... -
A priority-based ‘design for all’ approach to guide home designers for independent living
(Taylor & Francis, 2014-04-22)The aim is to provide a priority-based ‘design for all’ approach list that can be used as a guide in the architectural design process for independent living of the home users. It is important to prioritize ‘design for all’ ... -
Short-term dietary restriction in old zebrafish changes cell senescence mechanisms
(Elsevier, 2016-10)Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. Recent studies have shown, neurogenesis continues into adulthood but is known to be decreasing during advancing age ... -
Universal product design involving elderly users: a participatory design model
(Elsevier, 2004-07)Recent studies have shown that people prefer to age in their familiar environments, thus guiding designers to provide a safe and functionally appropriate environment for ageing people, regardless of their physical conditions ... -
Zebrafish aging models and possible interventions
(InTechOpen Press, 2018)Across the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the ... -
Zebrafish-A model organism for studying the neurobiological mechanisms underlying cognitive brain aging and use of potential interventions
(Frontiers Media S.A., 2018)Classically, the zebrafish model organism has been used to elucidate the genetic and cellular mechanisms related to development since the embryo forms and grows externally following fertilization. This provides insight ...
