Browsing by Keywords "Aging"
Now showing items 1-20 of 27
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Age and gender alter synaptic proteins in zebrafish (Danio Rerio) models of normal and delayed aging
(Bilkent University, 2017-07)Cognitive decline occurs during normal aging in some specific domains of cognitive abilities including but not limited to episodic memory, divided attention and executive functions, however, it is not a unitary decline ... -
Age related alterations of adult neurogenesis and astrocytes in Zebrafish (Danio Rerio)
(Bilkent University, 2019-09)Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. In order to identify appropriate interventions to change the course of brain aging and age-related neurological ... -
Age-dependent effects of short-term intermittent fasting and rapamycin treatment in Zebrafish (Danio Rerio) brain
(Bilkent University, 2020-05)World populations are rapidly aging, and there is an urgent need to develop interventions that prevent or reverse age-related deterioration of health. To date, several approaches have been developed to extend health span. ... -
Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio)
(Elsevier, 2017-06)The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ... -
Dietary and pharmacological interventions that inhibit mammalian target of rapamycin activity alter the brain expression levels of neurogenic and glial markers in an age-and treatment-dependent manner
(Mary Ann Liebert, 2020)Intermittent fasting (IF) and its mimetic, rapamycin extend lifespan and healthspan through mechanisms that are not fully understood. We investigated different short-term durations of IF and rapamycin on cellular and ... -
The difficult childhood of an adult: aging and maturity in Witold Gombrowicz’s pornografia
(Elsevier, 2020)Maturity and immaturity are the hallmarks of Witold Gombrowicz’s literary texts. They were introduced in his first novel, Ferdydurke, and an early collection of short stories, Memoirs from a Time of Immaturity, and continued ... -
Effects of aging and short-term dietary restriction on neurogenesis and cellular senescence in the zebrafish (Danio Reio) brain
(Bilkent University, 2016-09)Currently we know from rodent and fish studies that adult neuron generation is reduced but still continues in old animals with a dynamic change throughout aging. This process occurs mainly in hippocampal region, which is ... -
Effects of aging on gene expression levels of inflammatory, cytoskeletal and microglial markers in the brain using the zebrafish (Danio Rerio) model organism
(Bilkent University, 2021-01)Age-related cognitive decline burdens the elderly population, limiting their abil-ity to socialize and be independent. To be able to develop proper treatments, healthy aging should be examined. Previous studies focusing ... -
Effects of aging, diet and potential genetic interventions on the levels of Smurf2 and its interacting partners in Zebrafish (Danio Rerio) brain
(Bilkent University, 2020-09)Aging is a natural process that is ultimate combination of numerous intrinsic and extrinsic changes in an organism. Contrary the common belief, brain aging is not a loss of neurons while it has been shown that subtle ... -
Effects of caloric restriction on the antagonistic and integrative hallmarks of aging
(Elsevier, 2021)Aging is a significant risk factor for cognitive decline associated with neurodegenerative diseases, which makes understanding what promotes ‘healthy brain aging’ very important. Studies suggest that caloric restriction ... -
Endothelial progenitor cells display clonal restriction in multiple myeloma
(BioMed Central Ltd., 2006)Background: In multiple myeloma (MM), increased neoangiogenesis contributes to tumor growth and disease progression. Increased levels of endothelial progenitor cells (EPCs) contribute to neoangiogenesis in MM, and, ... -
Essays on macroeconomics
(Bilkent University, 2015-09)This dissertation consists of three essays on two topics in macroeconomics. The first essay focuses on the monetary policy implications in an aging society. The second and third essays revisit the famous Shimer puzzle ... -
Expression levels of SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) and its interacting partners show region-specific alterations during brain aging
(Elsevier, 2020)Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD ... -
Expression levels of TRPC1 and TRPC6 ion channels are reciprocally altered in aging rat aorta: implications for age-related vasospastic disorders
(American Aging Association, 2010)We previously showed that the expression of transient receptor potential canonical (TRPC)6 ion channel elevated when TRPC1 was knocked down in A7r5 cultured vascular smooth muscle cells. Therefore, the purpose of this study ... -
Expression of key synaptic proteins in Zebrafish (Danio Rerio) brain following caloric restriction and its mimetic and their relationship with gender
(Bilkent University, 2017-01)Aging is a progressive decline of physiological functioning and metabolic processes. Among all the organs, the brain seems to be the most vulnerable part of the body to the age-related changes because of the relatively ... -
Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic
(BioMed Central, 2014)Background: Brain aging is a multi-factorial process due to both genetic and environmental factors. The zebrafish has recently become a popular model organism for examining aging and age-related diseases because as ... -
Housing for the aging population
(Springer, 2007-04)Based on the concept of 'aging in place,' design of houses in the past years are explored. Design features in the built environment become barriers for aging people with functional limitations. Initially, houses were ... -
Investigating motion detection of aging zebrafish with optomotor response
(Bilkent University, 2021-07)Various aspects of visual functioning including motion perception have been shown to be significantly altered throughout aging. Contrary to the traditional view focusing on structural changes in the eye and retina, ... -
Investigating the mechanisms of telomere maintenance in zebrafish tissues and human brain cancer cell lines
(Bilkent University, 2019-09)Telomeres are nucleoprotein complexes formed at each end of the chromosomes to protect these ends from deterioration. In each round of cellular division, telomeric sequences shorten due to the end replication problem of ... -
Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases
(Elsevier Inc., 2016)Normal aging is accompanied by cognitive impairment with subtle cellular and molecular changes in the brain, whereas, pathological brain aging manifests as severe behavioral impairments with cellular pathology. Understanding ...
