Browsing by Keywords "A151 ODN"

Now showing items 1-3 of 3

Immunomodulatory potential of human umbilical cord tissue-derived mesenchymal stromal cell (UCX®) exosomes in combination with immunosuppressive “A151” oligodeoxynucleotide

Bulut, Özlem (Bilkent University, 2019-07)

Mesenchymal stromal or stem cells (MSCs) modulate immune responses apart from their regenerative capacities. Accumulating evidence suggests that MSCs exert their paracrine effects through extracellular vesicles known as ...
A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway

Yazar, Volkan; Kılıç, Gizem; Bulut, Özlem; Canavar-Yıldırım, Tuğçe; Yağcı, Fuat C.; Gamze, Aykut; Klinman, D. M.; Gürsel, M.; Gürsel, İhsan (Oxford University Press, 2020)

Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, ...
Therapeutic potential of an immunosuppressive oligodeoxynucleotide encapsulated within liposomes on bleomycin-induced mouse model of lung inflammation and fibrosis

Kılıç, Gizem (Bilkent University, 2019-05)

Systemic sclerosis (SSc) is an autoimmune/autoinflammatory disease with unknown etiology. It is characterized by vascular dysfunction, inflammation and disseminated fibrosis of skin or internal organs. Although its prevalence ...