Browsing by Author "Tombaz, Melike"
Now showing items 1-7 of 7
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Discovery of cancer-specific and independent prognostic gene subsets of the slit-robo family using TCGA-PANCAN datasets
(Mary Ann Liebert, 2021-12-08)The Slit-Robo family of axon guidance molecules works in concert, playing important roles in organ devel opment and cancer. Expressions of individual Slit-Robo genes have been used in calculating univariable hazard ratios ... -
Doxorubicin induces prolonged DNA damage signal in cells overexpressing DEK isoform-2
(Public Library of Science, 2022-10-03)DEK has a short isoform (DEK isoform-2; DEK2) that lacks amino acid residues between 49–82. The full-length DEK (DEK isoform-1; DEK1) is ubiquitously expressed and plays a role in different cellular processes but whether ... -
Extraction and prioritization of a gene-cancer-by-survival network involved in homeostasis of intracellular calcium concentrations using TCGA PANCAN data
(Mary Ann Liebert, Inc. Publishers, 2022-05-26)Regulation of intracellular calcium concentrations, [Ca++]i is important in maintaining the viability of normal as well as cancer cells and can be mediated by tumor microenvironment. Calcium release-activated calcium channel ... -
Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease
(Canadian Science Publishing, 2022-02-02)Human Angiotensin I Converting Enzyme 2 (ACE2) plays an essential role in blood pressure regulation and SARS-CoV-2 entry. ACE2 has a highly conserved, one-to-one ortholog (ace2) in zebrafish, which is an important model ... -
Global miRNA expression of bone marrow mesenchymal stem/stromal cells derived from Fanconi anemia patients
(Springer, 2021-11-18)Fanconi anemia (FA) is a rare genetic disorder characterized by genomic instability, developmental defects, and bone marrow (BM) failure. Hematopoietic stem cells (HSCs) in BM interact with the mesenchymal stem/stromal ... -
A shiny application for pancan survival analysis with paralog/miRNA pairs and in vitro validation of miRNA synergism in liver cancer
(Bilkent University, 2022-09)Emerging cancer survival tools can predict risk of disease and identify prognostic biomarkers. Multivariable Cox proportional hazards models with mRNA and microRNAs (miRNAs) expression can differentiate survival outcomes. ... -
SmulTCan: A Shiny application for multivariable survival analysis of TCGA data with gene sets
(Elsevier Ltd, 2021-10)Background Survival analysis is widely used in cancer research, and although several methods exist in R, there is the need for a more interactive, flexible, yet comprehensive online tool to analyze gene sets using Cox ...
