Now showing items 1-2 of 2

    • A highly potent TACC3 inhibitor as a novel anticancer drug candidate 

      Akbulut, Özge; Lengerli, D.; Saatci, Özge; Duman, Elif; Şeker, Urartu Özgür Şafak; Işık, A.; Akyol, A.; Çalışkan, B.; Banoğlu, E.; Şahin, Özgür (NLM (Medline), 2020)
      TACC3, a transforming acidic coiled-coil (TACC) family member, is frequently upregulated in a broad spectrum of cancers, including breast cancer. It plays critical roles in protecting microtubule stability and centrosome ...
    • SIK2 attenuates proliferation and survival of breast cancer cells with simultaneous perturbation of MAPK and PI3K/Akt pathways 

      Zohrap, N.; Saatci, Özge; Özeş, B.; Çoban, İ.; Atay, H. M.; Battaloğlu, E.; Şahin, Özgür; Buğra, K. (Impact Journals LLC, 2018)
      Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as ...