Browsing by Author "Ozturk, M."

Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells

Sayan, A. E.; Sayan, B. S.; Findikli, N.; Ozturk, M. (Nature Publishing Group, 2001)

p53 and p73 proteins activate similar target genes and induce apoptosis and cell cycle arrest. However, p53, but not p73 is considered a tumour-suppressor gene. Unlike p53, p73 deficiency in mice does not lead to a ...

Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism?

Irmak, M. B.; Ince, G.; Ozturk, M.; Cetin Atalay, R. (American Association for Cancer Research, 2003)

Selenium is essential to human health, and its deficiency is associated with different diseases including liver necrosis. Selenium is protective against viral hepatitis and hepatocellular carcinoma (HCC). The underlying ...

Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: identification of BRI3 and HSF2 as novel targets

Kavak, E.; Najafov, A.; Ozturk, N.; Seker, T.; Cavusoglu, K.; Aslan, T.; Duru, A. D.; Saygili, T.; Hoxhaj, G.; Hiz, M. C.; Unal, D. O.; Birgül-Iyison, N.; Ozturk, M.; Koman, A. (Elsevier, 2010)

The Wnt signaling pathway is involved in many differentiation events during embryonic development and can lead to tumor formation after aberrant activation of its components. β-catenin, a cytoplasmic component, plays a ...

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

Yuzugullu, H.; Benhaj, K.; Ozturk, N.; Senturk, S.; Celik, E.; Toylu, A.; Tasdemir, N.; Yilmaz, M.; Erdal, E.; Akcali, K. C.; Atabey, N.; Ozturk, M. (BioMed Central, 2009)

Background: β-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs). These mutations are associated with chromosomal stability, low ...

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

Cevik, D.; Yildiz G.; Ozturk, M. (WJG Press, 2015)

AIM: To determine the mutation status of human telomerase reverse transcriptase gene (TERT ) promoter region in hepatocellular carcinoma (HCC) from different geographical regions. METHODS: We analyzed the genomic DNA ...

Differential p21 expression after ionizing and UVC radiation in EBV-transformed lymphoblastoid cells

Moyret-Lalle, C.; Lalle P.; Pedeux, R.; Guillot, C.; Martel, S.; Magaud J.-P.; Puisieux, A.; Ozturk, M. (2000)

Responses to DNA-damaging agents appear to be coordinated by p53 through transcriptional activation of critical target genes. Among them, p21WAF1 encodes a protein preventing cells from entering S phase. It is not clear ...

Dose-and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment

Sucularli, C.; Senturk, S.; Ozturk, M.; Konu, O. (Springer Science+Business Media B.V., 2011)

Targets of E2F transcription factors effectively regulate the cell cycle from worms to humans. Furthermore, the dysregulation of E2F transcription modules plays a highly conserved role in cancers of human and zebrafish. ...

Double subband occupation of the two-dimensional electron gas in InxAl1-XN/AlN/GaN/AlN heterostructures with a low indium content (0.064 ≤ x ≤ 0.140) barrier

Lisesivdin, S. B.; Tasli, P.; Kasap, M.; Ozturk, M.; Arslan, E.; Ozcelik, S.; Özbay, Ekmel (Elsevier, 2010-05-08)

We present a carrier transport study on low indium content (0.064 ≤ x ≤ 0.140) InxAl1 - xN/AlN/GaN/AlN heterostructures. Experimental Hall data were carried out as a function of temperature (33-300 K) and a magnetic field ...

Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium

Erkekoglu, P.; Rachidi, W.; Yuzugullu, O. G.; Giray, B.; Favier, A.; Ozturk, M.; Hincal, F. (Elsevier, 2010)

Di(2-ethylhexyl)-phthalate (DEHP) is the most abundantly used phthalate derivative, inevitable environmental exposure of which is suspected to contribute to the increasing incidence of testicular dysgenesis syndrome in ...

The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographicaly diverse populations

Mazoyer, S.; Leary, J.; Kirk, J.; Fleischmann, E.; Wagner, T.; Claes, K.; Messiaen, L.; Foulkes, W.; Desrochers, M.; Simard, J.; Phelan, C. M.; Kwan, E.; Narod, S. A.; Vahteristo, P.; Nevanlinna, H.; Durando, X.; Bignon, Y. J.; Peyrat, J. P.; Bonnardel, C.; Sinilnikova, O. M.; Puget, N.; Lenoir, G. M.; Audoynaud, C.; Goldgar, D.; Maugard, C.; Caux, V.; Gad, S.; Stoppa-Lyonnet, D.; Noguès, C.; Lidereau, R.; Machavoine, C.; Bressac-De Paillerets, B.; Kuschel, B.; Betz, B.; Niederacher, D.; Beckmann, M. W.; Hamann, U.; Ponder, B. A. P.; Robinson, M.; Taylor G. R.; Bishop, T.; Catteau, A.; Solomon, E.; Cohen, B.; Steel, M.; Collins, N.; Stratton, M.; Van Der Looij, M.; Oláh, E.; Miller, N. J.; Barton, D. E.; Sverdlov, R. S.; Friedman, E.; Radice P.; Montagna, M.; Sensi, E.; Caligo, M.; Van Eijk, R.; Devilee, P.; Van Der Luijt, R.; Heimdal, K.; Møller, P.; Borg, Å.; Diez, O.; Cortes, J.; Domenech, M.; Baiget, M.; Osorio, A.; Benítez, J.; Maillet, P.; Sappino, A. P.; Özdag, H.; Özçelik, T.; Ozturk, M.; Rohlfs, E. M.; Boyd, J.; McDermott, D.; Offit, K.; Unger, M.; Nathanson, K.; Weber, B. L.; Sellers, T. A.; Hampton, E.; Couch, F. J.; Neuhausen, S.; Gayther, S. A. (Cell Press, 2000)

Recently, a 6-kb duplication of exon 13, which creates a frameshift in the coding sequence of the BRCA1 gene, has been described in three unrelated U.S. families of European ancestry and in one Portuguese family. Here, our ...

Experimental study of two-step growth of thin AlN film on 4H-SiC substrate by metalorganic chemical vapor deposition

Yu H.; Ozturk, M.; Demirel P.; Cakmak H.; Buyuklimanli, T.; Ou W.; Özbay, Ekmel (2010)

We report growth optimizations of the thin AlN film on (0001) 4H-SiC substrates by metalorganic chemical vapor deposition. The influence of growth conditions, such as growth temperature and the V/III molar ratio, on the ...

Expression of TAP73 and ΔNP73 in malignant gliomas

Ugur, H.; Sayan, A. E.; Ozdamar, S. O.; Kanpolat, Y.; Ozturk, M. (Spandidos Publications Ltd., 2004)

The p73 gene is able to encode transcriptionaly active TAp73, as well as a dominant-negatively acting ΔNp73 transcript isoforms. We studied differential expression of these forms in normal brain as well as glial tumors, ...

Genetic aspects of hepatocellular carcinogenesis

Ozturk, M. (1999)

Hepatocellular carcinoma (HCC) is linked etiologically to viruses (hepatitis B virus [HBV] and hepatitis C virus [HCV]), chemical carcinogens (i.e., aflatoxins), and other environmental and host factors causing chronic ...

Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis

Yildiz, G.; Arslan Ergul, A.; Bagislar, S.; Konu, O.; Yuzugullu, H.; Gursoy Yuzugullu, O.; Ozturk, N.; Ozen, C.; Ozdag, H.; Erdal, E.; Karademir, S.; Sagol, O.; Mizrak, D.; Bozkaya, H.; Ilk, H. G.; Ilk, O.; Bilen, B.; Cetin Atalay, R.; Akar, N.; Ozturk, M. (PLOS ONE, 2013)

Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development. Most tumor cells are believed ...

Germline hMSH2 and hMLH1 gene mutations in incomplete HNPCC families

Wang, Q.; Desseigne, F.; Lasset, C.; Saurin J. C.; Navarro, C.; Yagci, T.; Keser I.; Bagci, H.; Luleci, G.; Gelen, T.; Chayvialle, J.-A.; Puisieux, A.; Ozturk, M. (1997)

Hereditary non-polyposis colon cancer (HNPCC) is a common hereditary disease characterized by a predisposition to an early onset of colorectal cancer. The majority of the HNPCC families carry germline mutations of either ...

Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts

Ors, A.; Papin, C.; Favier, B.; Roulland, Y.; Dalkara, D.; Ozturk, M.; Hamiche, A.; Dimitrov, S.; Padmanabhan, K. (Canadian Science Publishing, 2017)

H3.3 is a histone variant that marks transcription start sites as well as telomeres and heterochromatic sites on the genome. The presence of H3.3 is thought to positively correlate with the transcriptional status of its ...

Homozygosity at variant MLH1 can lead to secondary mutation in NF1, neurofibromatosis type I and early onset leukemia

Alotaibi, H.; Ricciardone, M. D.; Ozturk, M. (Elsevier, 2008)

Heterozygous germ-line variants of DNA mismatch repair (MMR) genes predispose individuals to hereditary non-polyposis colorectal cancer. Several independent reports have shown that individuals constitutionally homozygous ...

Identification of BTG2, an antiproliferative, p53-dependent component of the DNA damage cellular response pathway

Rouault, J. P.; Falette, N.; Falette, V.; Guillot, C.; Rimokh, R.; Wang, Q.; Berthet, C.; Lalle, C.; Savatier, P.; Pain, B.; Ozturk, M.; Samaru, C.; Puisi, A. (Nature Publishing Group, 1996)

Identification of genes induced by BRCA1 in breast cancer cells

Atalay, A.; Crook, T.; Ozturk, M.; Yulug, I. G. (Academic press, 2002)

Inherited mutations of the BRCA1 gene predispose to breast, ovarian, and other cancers. The role of the BRCA1 gene in the maintenance of chromosomal integrity is linked to a number of biological properties of its protein ...

Immunization with UV-induced apoptotic cells generates monoclonal antibodies against proteins differentially expressed in hepatocellular carcinoma cell lines

Celikkaya, H.; Ciraci, C.; Oztas, E.; Avci, M. E.; Ozturk, M.; Yagci, T. (Mary Ann Liebert, Inc, 2007)

Early and differential diagnosis of hepatocellular carcinoma (HCC) requires sensitive and specific tissue and serum markers. On the other hand, proteins involved in tumorigenesis are extensively modelated on exposure to ...