Browsing by Author "Konu, Özlen"
Now showing items 1-18 of 18
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Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
(Elsevier, 2021-06-24)Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter ... -
Convergence between nicotine and leptin signaling in body weight regulation and obesity
(Nova Publishers, 2004)Obesity continues to be one of the major epidemic problems in the U. S. and many other industrialized nations. Although treatment strategies historically targeted small-molecule neurotransmitters, more recently it became ... -
CoVrimer: a tool for aligning SARS-CoV-2 primer sequences and selection of conserved/degenerate primers
(Academic Press, 2021-07-20)As mutations in SARS-CoV-2 virus accumulate rapidly, novel primers that amplify this virus sensitively and specifically are in demand. We have developed a webserver named CoVrimer by which users can search for and align ... -
Cryptic torrent frogs of myanmar: an examination of the amolops marmoratus species complex with the resurrection of amolops afghanus and the identification of a new species
(American Society of Ichthyologists and Herpetologists, 2012)We investigated diversity in the Amolops marmoratus species complex within Myanmar using both molecular and morphological characters from recently collected specimens. Based on congruence between multivariate analyses of ... -
Design, synthesis and anticancer/antiestrogenic activities of novel indole-benzimidazoles
(Elsevier , 2020-05)Indole-benzimidazoles have recently gained attention due to their antiproliferative and antiestrogenic effects. However, their structural similarities and molecular mechanisms shared with selective estrogen receptor ... -
Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts
(Royal Society of Chemistry, 2021-04-26)Cancer poses a world-wide healthcare problem, demanding selective and effective therapy protocols. To address that, a vast amount of therapeutic candidates are being investigated in the field of medicinal chemistry. ... -
Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines
(Nature Publishing Group, 2018)Acetylcholinesterase (AChE), an enzyme responsible for degradation of acetylcholine, has been identified as a prognostic marker in liver cancer. Although in vivo Ache tumorigenicity assays in mouse are present, no established ... -
Discovery of cancer-specific and independent prognostic gene subsets of the slit-robo family using TCGA-PANCAN datasets
(Mary Ann Liebert, 2021-12-08)The Slit-Robo family of axon guidance molecules works in concert, playing important roles in organ devel opment and cancer. Expressions of individual Slit-Robo genes have been used in calculating univariable hazard ratios ... -
Doxorubicin induces prolonged DNA damage signal in cells overexpressing DEK isoform-2
(Public Library of Science, 2022-10-03)DEK has a short isoform (DEK isoform-2; DEK2) that lacks amino acid residues between 49–82. The full-length DEK (DEK isoform-1; DEK1) is ubiquitously expressed and plays a role in different cellular processes but whether ... -
Extraction and prioritization of a gene-cancer-by-survival network involved in homeostasis of intracellular calcium concentrations using TCGA PANCAN data
(Mary Ann Liebert, Inc. Publishers, 2022-05-26)Regulation of intracellular calcium concentrations, [Ca++]i is important in maintaining the viability of normal as well as cancer cells and can be mediated by tumor microenvironment. Calcium release-activated calcium channel ... -
Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease
(Canadian Science Publishing, 2022-02-02)Human Angiotensin I Converting Enzyme 2 (ACE2) plays an essential role in blood pressure regulation and SARS-CoV-2 entry. ACE2 has a highly conserved, one-to-one ortholog (ace2) in zebrafish, which is an important model ... -
Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced kidney injury
(American Physiological Society, 2021-04-08)Serum and glucocorticoid-regulated kinase 1 (SGK1) stimulates aldosterone-dependent renal Na reabsorption and modulates blood pressure. In addition, genetic ablation or pharmacological inhibition of SGK1 limits the development ... -
Investigation and comparison of the preprocessing algorithms for microarray analysis for robust gene expression calculation and performance analysis of technical replicates
(IEEE, 2006)Preprocessing of microarray data involves the necessary steps of background correction, normalization and summarization of the raw intensity data obtained from cDNA or oligo-arrays before statistical analysis. Several ... -
Lower connectivity of tumor coexpression networks is not specific to cancer
(IOP, 2019-05)Global level network analysis of molecular links is necessary for systems level view of complex diseases like cancer. Using genome-wide expression datasets, we constructed and compared gene co-expression based specific ... -
mESAdb: microRNA expression and sequence analysis database
(Oxford University Press, 2011)MicroRNA expression and sequence analysis database (http://konulab.fen. bilkent.edu.tr/mirna/) (mESAdb) is a regularly updated database for the multivariate analysis of sequences and expression of microRNAs from multiple ... -
PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors
(Springer, 2019)HOX and TALE transcription factors are important regulators of development and homeostasis in determining cellular identity. Deregulation of this process may drive cancer progression. The aim of this study was to investigate ... -
Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells
(Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2021-04-20)Hepatocellular carcinoma (HCC) is one of the most common cancer types with high mortality rates and displays increased resistance to various stress conditions such as oxidative stress. Conventional therapies have low ... -
ZenoFishDb v1.1: a database for xenotransplantation studies in zebrafish
(Mary Ann Liebert, 2020)Rapidly accumulating literature has proven feasibility of the zebrafish xenograft models in cancer research. Nevertheless, online databases for searching the current zebrafish xenograft literature are in great demand. ...
