Now showing items 1-2 of 2

    • Inositol‐requiring enzyme‐1 regulates phosphoinositide signaling lipids and macrophage growth 

      Hamid, S. M.; Çıtır, M.; Terzi, E. M.; Çimen, İ.; Yıldırım, Zehra; Doğan, Aslı Ekin; Kocatürk, B.; Onat, Umut Inci; Arditi, M.; Weber, C.; Traynor‐Kaplan, A.; Schultz, C.; Erbay, E. (Wiley-VCH Verlag, 2020-11)
      The ER‐bound kinase/endoribonuclease (RNase), inositol‐requiring enzyme‐1 (IRE1), regulates the phylogenetically most conserved arm of the unfolded protein response (UPR). However, the complex biology and pathology regulated ...
    • Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation 

      Çimen, I.; Kocatürk, B.; Koyuncu, S.; Tufanlı, Ö.; Onat, U. I.; D. Yıldırım, A.; Apaydın, O.; Demirsoy, Ş.; G. Aykut, Z.; T. Nguyen, U.; Watkins, S. M.; Hotamışlıgil, G. S.; Erbay, E. (American Association for the Advancement of Science (AAAS), 2016-09)
      De novo lipogenesis (DNL), the conversion of glucose and other substrates to lipids, is often associated with ectopic lipid accumulation, metabolic stress, and insulin resistance, especially in the liver. However, ...