Browsing by Author "Kayhan, Merve"
Now showing items 1-4 of 4
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Adenosine receptor signaling targets both PKA and epac pathways to polarize dendritic cells to a suppressive phenotype
(American Association of Immunologists, 2019)Extracellular adenosine accumulates in tumors and causes suppression of immune cells. Suppressive adenosine signaling is achieved through adenosine A2A and A2B receptors, which are Gs coupled, and their activation elevates ... -
Interleukin-7 protects CD8+ T cells from adenosine-mediated immunosuppression
(American Association for the Advancement of Science (AAAS), 2021-03-16)The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8+ T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes ... -
Molecular mechanism for adenosine regulation of dendritic cells
(Bilkent University, 2017-05)Cell death, inflammation or other cellular stress factors cause accumulation of adenosine in the extracellular space. Adenosine has immunosuppressive effects on antigen presenting cells. However, molecular mechanisms for ... -
Reactivation of cAMP pathway by PDE4D inhibition represents a novel druggable axis for overcoming tamoxifen resistance in ER-positive breast cancer
(American Association for Cancer Research, 2018)Purpose: Tamoxifen remains an important hormonal therapy for ER-positive breast cancer; however, development of resistance is a major obstacle in clinics. Here, we aimed to identify novel mechanisms of tamoxifen resistance ...
