Browsing by Author "Gürsel, İhsan"
Now showing items 1-20 of 27
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3D-MSCs A151 ODN-loaded exosomes are immunomodulatory and reveal a proteomic cargo that sustains wound resolution
(Elsevier B.V., 2022-11)Introduction: Non-healing wounds remain a major burden due to the lack of effective treatments. Mesenchymal stem cell-derived exosomes (MSC-Exo) have emerged as therapeutic options given their pro-regenerative and ... -
Administration of bone marrow derived mesenchymal stem cells modulate tlr expression during liver regeneration
(Trakya Üniversitesi, 2019)Liver cell transplantation is a powerful alternative to orthotopic cell transplantation in the treatment of liver failures. Recently, considerable effort is being channeled to understand the nature and kinetics of directing ... -
Bacteriocin DNA nanocomplexes as immunotherapeutic carriers
(Association for Cancer Immunotherapy, 2012-05)Synthetic oligodeoxynucleotides (CpG-ODNs) and bacterial DNA containing unmethylated CpG dinucleotides (CpG motifs) are clinical candidates as anti-cancer agents, immune adjuvants, anti-allergens, and stand alone ... -
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes
(American Physiological Society, 2021-11-09)Since previous research suggests a role of a circulating factor in the pathogenesis of steroid-sensitive nephrotic syndrome (NS), we speculated that circulating plasma extracellular vesicles (EVs) are a candidate source ... -
Co-encapsulating nucleic acid based TLR ligands in nanoliposomes induce potent antiviral immune activation
(European Molecular Biology Organization, 2012-05) -
Contribution of plasma microparticles to the clinical manifestation of allergic diseases
(Turkish Society of Immunology, 2012-04)Microparticles (MPs) are nanovesicles secreted from wide variety of cells. They have role in cellular communications in addition to their physiological roles in several diseases. In this study, we investigated roles of MPs ... -
Could individuals from countries using BCG vaccination be resistant to SARS-CoV-2 induced infections?
(Turkish Society of Immunology, 2020)The lower than expected number of SARS-CoV-2 cases in countries with fragile health systems is puzzling. Herein, we hypothesize that BCG vaccination policies and vaccine strain preferences adopted by different countries ... -
CpG loaded flourescent polymeric nanoparticles: a theranostic drug delivery system suitable for TLR based therapies
(Turkish Society of Immunology, 2012-04)Designing nanoparticulate delivery systems suitable for simultaneous imaging have been attracting great interest. Several systems such as liposomes, micelles, dendrimers, nanospheres and nanocapsules are potential theranostic ... -
CpG ODN loaded exosome nanovesicles: enhanced immunostimulatory activity
(Turkish Society of Immunology, 2012-04)Exosomes are naturally occurring, membranous nanovesicles known to function as intercellular communication vectors. To explore whether these naturally occuring bilayer vesicles could be exploited as a nucleic acid delivery ... -
CpG Oligodeoxynucleotides enhances both humoral and cellular immune responses against FMDV in mice
(Association for Cancer Immunotherapy, 2012-05)Foot and Mouth Disease is one of the major contagious and devastating viral diseases which is caused by FMD virus (FMDV) of the cloven hoofed animals. FMD outbreaks all around the world caused serious economical losses ... -
Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infection
(Wiley-Blackwell Publishing Ltd., 2021-09-14)Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes the development and immunogenicity of SARS-CoV-2 VLP ... -
Development of CpG ODN based vaccine adjuvant formulations
(Humana Press, New York, 2016) -
Dual-adjuvant effect of pH-sensitive liposomes loaded with STING and TLR9 agonists regress tumor development by enhancing Th1 immune response
(Elsevier, 2020)Nucleic acid-based pattern recognition receptor agonists are effective adjuvants and immunotherapeutic agents. Rather than single applications, ligand combinations could synergistically potentiate immune responses by ... -
Effects of obesity on airway and systemic inflammation in asthmatic children
(S. Karger AG, 2021-03-22)Obese asthma is a complex syndrome with certain phenotypes that differ in children and adults. There is no clear evidence regarding the presence of additive or synergistic pathological interaction between obesity and asthma ... -
Human gut commensal membrane vesicles modulate inflammation by generating m2-like macrophages and myeloid-derived suppressor cells
(American Association of Immunologists, 2020)Immunomodulatory commensal bacteria modify host immunity through delivery of regulatory microbial-derived products to host cells. Extracellular membrane vesicles (MVs) secreted from symbiont commensals represent one such ... -
Immunostimulatory activity of CpG-ODN is enhanced via encapsulation into nanovesicles
(European Molecular Biology Organization, 2012-05) -
Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infection
(Scientific and Technical Research Council of Turkey, 2020)Discovery of novel and broad-acting immunomodulators is of critical importance for the prevention and treatment of disorders occurring due to overexuberant immune responseincluding SARS-CoV-2 triggered cytokine storm leading ... -
Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
(Wiley, 2020)Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non‐infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination ... -
Nanoliposomes encapsulating nucleic acid based TLR ligands induce inflammasome mediated potent immune activation
(Turkish Society of Immunology, 2012-04)
