Now showing items 1-4 of 4

    • Cancer stem cell biology 

      Chau, Tieu Lan; Xhafa, Erta; Göktuna, Serkan İsmail (Trakya Üniversitesi, 2019)
      Cancer is becoming the leading cause of death all around the world. To develop better therapeutic options against cancer, we need a thorough understanding of tumor development and dissemination. As our knowledge increases, ...
    • IKBKE inhibits TSC1 to activate the mTOR/S6K pathway for oncogenic transformation 

      Göktuna, Serkan İsmail (TUBITAK, 2018)
      IKBKE (IKKε) has emerged as a key modulator of multiple substrates, controlling oncogenic pathways in various malignancies. mTOR signaling, required for cellular growth, proliferation, and vascular angiogenesis in cancer, ...
    • IKKs and tumor cell plasticity 

      Göktuna, Serkan İsmail; Diamanti, M. A.; Chau, T. L. (Wiley-Blackwell Publishing Ltd., 2018)
      Nuclear factor κB (NF-κB) transcription factors are the central hubs of signaling pathways connecting proinflammatory signals to cell survival, proliferation and cytokine production. In cancers, NF-κB signaling influences ...
    • Role of non-coding RNAs as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways 

      Esmaeili, M.; Keshani, M.; Vakilian, M.; Esmaeili, M.; Peymani, M.; Forootan, F. S.; Chau, Tieu Lan; Göktuna, Serkan İsmail; Zaker, S. R.; Esfahani, M. H. N.; Ghaedi, K. (Elsevier, 2020)
      Colorectal cancer (CRC) is one of the most common types of cancer which affects the colon and the rectum. Approximately one third of annual CRC mortality occurs due to the late detection of this type of cancer. Therefore, ...